{"id":"8f696e16-2bb5-5f20-a898-9ced5bb0c42b","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-review-reactive-species-framing","predicate":"generates","statement":"The review states that the principal mechanisms of hyperbaric oxygen are based on intracellular generation of reactive species of oxygen and nitrogen, which act through cell signal transduction cascades.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"7388b38e-350d-58ca-a782-bb9a64044b92","mechanism_event_label":"The therapy works by making the cell produce reactive molecules that carry signals, not simply by supplying more oxygen.","subject":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"object":{"id":"b51f3150-efc0-5413-a47a-01d094d248b7","slug":"reactive-oxygen-species","display_name":"Reactive oxygen species","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"7388b38e-350d-58ca-a782-bb9a64044b92","stable_key":"488ea171-36b8-5ef6-b5d3-98563980fdbf:hbot-review-reactive-species-framing-event","event_type":"observed_intervention","label":"The therapy works by making the cell produce reactive molecules that carry signals, not simply by supplying more oxygen.","description":"The review states that the principal mechanisms of hyperbaric oxygen are based on intracellular generation of reactive species of oxygen and nitrogen, which act through cell signal transduction cascades.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"da9b47f9-30f8-5579-88a2-a02a3404e978","slug":"reactive-nitrogen-species","display_name":"Reactive nitrogen species","entity_type_key":"chemical_species"},"role":"co_product","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"899c7ab0-6f81-5b38-a6bd-fbb33d66ac8d","slug":"oxygen","display_name":"Molecular oxygen","entity_type_key":"small_molecule"},"role":"supplied_gas","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"581fa746-cb84-571b-87a0-4d461263f660","slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"b51f3150-efc0-5413-a47a-01d094d248b7","slug":"reactive-oxygen-species","display_name":"Reactive oxygen species","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/hbot-research/21200283.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"541f2eb700a843e35093e589069b7839f1a3577c2de8cd1edb444698c1379380\", \"start_char\": 0, \"end_char\": 1120, \"text_sha256\": \"541f2eb700a843e35093e589069b7839f1a3577c2de8cd1edb444698c1379380\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Narrative review of therapeutic mechanisms and clinical trial evidence","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Hyperbaric oxygen as used clinically, typically 2.0 to 2.5 atmospheres absolute","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A narrative review, not a primary experiment. It is recorded as the framing source the reader was given; every mechanism it names is also recorded here from its own primary paper.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hyperbaric-oxygen","display_name":"Hyperbaric oxygen therapy","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human, with supporting animal work","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The therapy works by making the cell produce reactive molecules that carry signals, not simply by supplying more oxygen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hbot-p21200283] Hyperbaric oxygen: its mechanisms and efficacy. (2011). https://pubmed.ncbi.nlm.nih.gov/21200283/ DOI: 10.1097/prs.0b013e3181fbe2bf","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Multiple tissues","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0907b00e-7f62-54f9-9567-fc707968b425","evidence_kind":"source_excerpt","locator":"Lines 62-73","start_line":62,"end_line":73,"excerpt":"### hbot-review-reactive-species-framing\nThe review states that the principal mechanisms of hyperbaric oxygen are based on intracellular generation of reactive species of oxygen and nitrogen, which act through cell signal transduction cascades.\nCondition category: normal\nnutrient_topic: Hyperbaric oxygen research collection; topical membership is not evidence of a direct clinical effect, and a therapeutic exposure is not a dietary intake.\nplain_language: The therapy works by making the cell produce reactive molecules that carry signals, not simply by supplying more oxygen.\norganism: Human, with supporting animal work\ntissue_or_cell_type: Multiple tissues\nexperimental_model: Narrative review of therapeutic mechanisms and clinical trial evidence\nlimitations: A narrative review, not a primary experiment. It is recorded as the framing source the reader was given; every mechanism it names is also recorded here from its own primary paper.\nexposure: Hyperbaric oxygen as used clinically, typically 2.0 to 2.5 atmospheres absolute\nevidence_span: {\"source_cache\": \"artifacts/hbot-research/21200283.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"541f2eb700a843e35093e589069b7839f1a3577c2de8cd1edb444698c1379380\", \"start_char\": 0, \"end_char\": 1120, \"text_sha256\": \"541f2eb700a843e35093e589069b7839f1a3577c2de8cd1edb444698c1379380\"}\n[hbot-p21200283] Hyperbaric oxygen: its mechanisms and efficacy. (2011). https://pubmed.ncbi.nlm.nih.gov/21200283/ DOI: 10.1097/prs.0b013e3181fbe2bf","model_system":"Narrative review of therapeutic mechanisms and clinical trial evidence","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [hbot-p21200283] Hyperbaric oxygen: its mechanisms and efficacy. (2011). https://pubmed.ncbi.nlm.nih.gov/21200283/ DOI: 10.1097/prs.0b013e3181fbe2bf","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dbf39b48-c95e-5291-b404-349ffbc4488f","stable_key":"import-488ea171-36b8-5ef6-b5d3-98563980fdbf","title":"Hyperbaric oxygen: the exposure, its reactive species, the signals they carry, and the nutrient-dependent enzymes that handle them (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"fb2443321804010d82c6b96ab61cc51b4b6628ddbb15751cb0e90b491606e79c","revision_id":"bb699ea5-b492-5728-b22c-48f0842a8ac9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}