{"id":"8f0d5c26-c316-5af0-86f7-e08a72421495","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-mrp-efflux-block","predicate":"reduces","statement":"MK571 reduced glutathione efflux during erythrocyte vanadate exposure, suggesting involvement of an MRP-family exporter.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5becd2ac-b2fe-50a9-9b8f-fe2272469547","mechanism_event_label":"An exporter can contribute to loss of cellular glutathione.","subject":{"id":"8f6a81db-52b9-5c7d-9052-50ab0dac2396","slug":"human-erythrocyte-mrp-inhibition","display_name":"MRP-inhibitor experiment in human erythrocytes","entity_type_key":"cellular_process"},"object":{"id":"1ad15cf2-df32-5ea0-83f3-30317902aab7","slug":"human-erythrocyte-vanadate-gsh-efflux","display_name":"Glutathione efflux from vanadate-exposed human erythrocytes","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5becd2ac-b2fe-50a9-9b8f-fe2272469547","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-mrp-efflux-block-event","event_type":"observed_relationship","label":"An exporter can contribute to loss of cellular glutathione.","description":"MK571 reduced glutathione efflux during erythrocyte vanadate exposure, suggesting involvement of an MRP-family exporter.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8f6a81db-52b9-5c7d-9052-50ab0dac2396","slug":"human-erythrocyte-mrp-inhibition","display_name":"MRP-inhibitor experiment in human erythrocytes","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1ad15cf2-df32-5ea0-83f3-30317902aab7","slug":"human-erythrocyte-vanadate-gsh-efflux","display_name":"Glutathione efflux from vanadate-exposed human erythrocytes","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bef86a6e-28a0-5df9-9306-3f05991aa159","slug":"vanadate-v","display_name":"Vanadate(V), protonation/speciation dependent","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b44c9e27-4bbb-52d3-a022-14cddded5073","slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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primary references, access levels and experimental limitations individually identified. 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