{"id":"8eb7eb14-6338-5b3c-adbe-852b6d7313b3","stable_key":"research:neural-selenoi-loss-impairs-myelin","predicate":"loss-decreases","statement":"Neural-lineage Selenoi deletion impaired myelination in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"negative","is_public":true,"mechanism_event_id":"1043ecf9-7250-5034-bc95-9b588c47be5c","mechanism_event_label":"Loss of neural SELENOI disrupted myelin formation.","subject":{"id":"8334e065-581a-5500-b664-dbe129850043","slug":"selenoi","display_name":"SELENOI","entity_type_key":"protein"},"object":{"id":"e102c90b-8496-5887-bca3-122fc225b1e3","slug":"myelination","display_name":"Neural myelination","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1043ecf9-7250-5034-bc95-9b588c47be5c","stable_key":"research:neural-selenoi-loss-impairs-myelin","event_type":"genetic-perturbation","label":"Loss of neural SELENOI disrupted myelin formation.","description":"Neural-lineage Selenoi deletion impaired myelination in mice.","status":"active","compartment":{"slug":"nervous-system","display_name":"Nervous system"},"participants":[{"entity":{"id":"8334e065-581a-5500-b664-dbe129850043","slug":"selenoi","display_name":"SELENOI","entity_type_key":"protein"},"role":"perturbed-protein","stoichiometry":null,"state_label":"deleted","sequence_order":0,"notes":""},{"entity":{"id":"e102c90b-8496-5887-bca3-122fc225b1e3","slug":"myelination","display_name":"Neural myelination","entity_type_key":"cellular_process"},"role":"measured-process","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e1c84730-eb0b-5cd8-a221-dba93bc025d1","slug":"plasmenyl-pe","display_name":"Plasmenylethanolamine","entity_type_key":"lipid"},"role":"altered-lipid-pool","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cell_type","value_text":"neural lineage","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Tuba1a-Cre conditional knockout","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not identify one lipid species as the sole cause.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"mouse","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f2b1f6c2-cd06-5db1-9f48-8181c33c2251","evidence_kind":"curated_literature_summary","locator":"lines 762-772","start_line":762,"end_line":772,"excerpt":"## neural-selenoi-loss-impairs-myelin\n\nLoss of neural SELENOI disrupted myelin formation.\n\nNeural-lineage Selenoi deletion impaired myelination in mice.\n\nOrganism: mouse\nCell type: neural lineage\nExperimental model: Tuba1a-Cre conditional knockout\nLimitations: Does not identify one lipid species as the sole cause.\nPrimary reference: [Selenoprotein I is indispensable for ether lipid homeostasis and proper myelination](https://pubmed.ncbi.nlm.nih.gov/38582453/)","model_system":"Tuba1a-Cre conditional knockout","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[],"research":{"topic":"neural-lipid-homeostasis","plain_language":"Loss of neural SELENOI disrupted myelin formation.","evidence_scope":"direct_experimental","papers":[{"key":"nunes-2024-selenoi-myelin","title":"Selenoprotein I is indispensable for ether lipid homeostasis and proper myelination","url":"https://pubmed.ncbi.nlm.nih.gov/38582453/","doi":"10.1016/j.jbc.2024.107259","year":2024,"model":"Neural-lineage Selenoi knockout mice","summary":"Links disturbed ether-lipid balance to impaired myelination and increased lipid peroxidation; Sec function remains unsettled."}]}}