{"id":"8e8c97fe-0352-5229-8b7e-f435ef28f7e7","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-rat-mg-amino-acid-context","predicate":"low_intake_reduces","statement":"Boron-deprived rats with marginal methionine had lower bone magnesium; interactions with magnesium deprivation were strongest under severe restriction and abundant arginine.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"21921cf1-6b4a-56ce-9962-ddd9f664cd1e","mechanism_event_label":"The effect of low boron depended strongly on the rest of the diet.","subject":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"object":{"id":"ac06d7ce-104b-5e9e-a594-d9b5b14ab0c5","slug":"bone-magnesium-concentration","display_name":"Bone magnesium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"21921cf1-6b4a-56ce-9962-ddd9f664cd1e","stable_key":"7edf94bb-95c8-5234-9161-9eb338bb9b36:boron-rat-mg-amino-acid-context-event","event_type":"observed_intervention","label":"The effect of low boron depended strongly on the rest of the diet.","description":"Boron-deprived rats with marginal methionine had lower bone magnesium; interactions with magnesium deprivation were strongest under severe restriction and abundant arginine.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"dietary_context","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5144a867-de17-599d-baec-68500e3d40bd","slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ac06d7ce-104b-5e9e-a594-d9b5b14ab0c5","slug":"bone-magnesium-concentration","display_name":"Bone magnesium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/boron-research/2484371.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"324fa75871a385d9890c32c6d4ddd62af6fff561174e439afb94f3bd4662ed13\", \"start_char\": 0, \"end_char\": 2179, \"text_sha256\": \"324fa75871a385d9890c32c6d4ddd62af6fff561174e439afb94f3bd4662ed13\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nine factorial dietary experiments in rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Six to ten weeks; boron supplement 0 or 3 µg/g; magnesium 100/200 versus 400 µg/g; methionine and arginine contexts varied","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dependence on severe magnesium restriction and amino-acid background is central. Rat growth/bone findings do not establish an essential human role, a methylation mechanism or a human rescue regimen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Sprague-Dawley rats and one spontaneously hypertensive rat experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The effect of low boron depended strongly on the rest of the diet.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p2484371] Magnesium and methionine deprivation affect the response of rats to boron deprivation. (1988). https://pubmed.ncbi.nlm.nih.gov/2484371/ DOI: 10.1007/bf02795449","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-animal growth and bone mineral endpoints","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"34b7cf84-5b1e-522a-9324-44178e01230e","evidence_kind":"source_excerpt","locator":"Lines 794-805","start_line":794,"end_line":805,"excerpt":"### boron-rat-mg-amino-acid-context\nBoron-deprived rats with marginal methionine had lower bone magnesium; interactions with magnesium deprivation were strongest under severe restriction and abundant arginine.\nCondition category: nutrient_deficiency\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The effect of low boron depended strongly on the rest of the diet.\norganism: Sprague-Dawley rats and one spontaneously hypertensive rat experiment\ntissue_or_cell_type: Whole-animal growth and bone mineral endpoints\nexperimental_model: Nine factorial dietary experiments in rats\nlimitations: Dependence on severe magnesium restriction and amino-acid background is central. Rat growth/bone findings do not establish an essential human role, a methylation mechanism or a human rescue regimen.\nexposure: Six to ten weeks; boron supplement 0 or 3 µg/g; magnesium 100/200 versus 400 µg/g; methionine and arginine contexts varied\nevidence_span: {\"source_cache\": \"artifacts/boron-research/2484371.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"324fa75871a385d9890c32c6d4ddd62af6fff561174e439afb94f3bd4662ed13\", \"start_char\": 0, \"end_char\": 2179, \"text_sha256\": \"324fa75871a385d9890c32c6d4ddd62af6fff561174e439afb94f3bd4662ed13\"}\n[boron-p2484371] Magnesium and methionine deprivation affect the response of rats to boron deprivation. (1988). https://pubmed.ncbi.nlm.nih.gov/2484371/ DOI: 10.1007/bf02795449","model_system":"Nine factorial dietary experiments in rats","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [boron-p2484371] Magnesium and methionine deprivation affect the response of rats to boron deprivation. (1988). https://pubmed.ncbi.nlm.nih.gov/2484371/ DOI: 10.1007/bf02795449","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2d96c547-aeec-5d8b-9d31-1288da209f89","stable_key":"import-7edf94bb-95c8-5234-9161-9eb338bb9b36","title":"Boron: chemistry, nutrient interactions, low-intake studies and mechanistic uncertainties (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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