{"id":"8e819410-0ec4-5923-8826-25380b4362b5","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-glycine-receptor-alpha1","predicate":"activates","statement":"Applied taurine activated recombinant human alpha1 homomeric glycine receptors in oocytes and HEK293 cells; its potency and efficacy varied with the experimental receptor response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7d864155-0e3c-54e9-ab57-08cb051bfcfa","mechanism_event_label":"Taurine can activate a receptor named for glycine.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"b40b5391-68b1-5939-86b2-fa3b7e7681d8","slug":"human-glra1-homomer","display_name":"Human alpha1 homomeric glycine receptor","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"7d864155-0e3c-54e9-ab57-08cb051bfcfa","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-glycine-receptor-alpha1-event","event_type":"observed_relationship","label":"Taurine can activate a receptor named for glycine.","description":"Applied taurine activated recombinant human alpha1 homomeric glycine receptors in oocytes and HEK293 cells; its potency and efficacy varied with the experimental receptor response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b40b5391-68b1-5939-86b2-fa3b7e7681d8","slug":"human-glra1-homomer","display_name":"Human alpha1 homomeric glycine receptor","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human receptor expressed in Xenopus oocytes or human cells; electrophysiology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a clinical sedative effect; chloride gradient and receptor composition shape cellular response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Taurine can activate a receptor named for glycine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11559772/ · DOI 10.1111/j.1469-7793.2001.t01-1-00741.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"af2df2ac-c2a2-56fe-af0b-61e5323c7796","evidence_kind":"source_excerpt","locator":"Lines 417-423","start_line":417,"end_line":423,"excerpt":"## taurine-glycine-receptor-alpha1\nTaurine can activate a receptor named for glycine.\nApplied taurine activated recombinant human alpha1 homomeric glycine receptors in oocytes and HEK293 cells; its potency and efficacy varied with the experimental receptor response.\nModel: Human receptor expressed in Xenopus oocytes or human cells; electrophysiology.\nLimitations: Not a clinical sedative effect; chloride gradient and receptor composition shape cellular response.\nEvidence access: Primary abstract\nActivation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11559772/ · DOI 10.1111/j.1469-7793.2001.t01-1-00741.x","model_system":"Human receptor expressed in Xenopus oocytes or human cells; electrophysiology.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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