{"id":"8e71f96c-694d-5e45-9a01-367f82b68639","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-gpd2-loss","predicate":"loss_sensitizes_to","statement":"GPD2 deletion sensitized cancer cells to GPX4-inhibition-induced mitochondrial lipid peroxidation and ferroptosis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c6acc8ba-a7ef-53de-b38c-a84f9cef7786","mechanism_event_label":"Dependence on one pathway changed when the parallel defense was blocked.","subject":{"id":"e3a468b0-08ac-57a3-8df4-942934b35b2a","slug":"gpd2","display_name":"Human mitochondrial glycerol-3-phosphate dehydrogenase / GPD2","entity_type_key":"protein"},"object":{"id":"b19acf65-87db-5ba1-bb18-a87e4b05af3d","slug":"mitochondrial-lipid-peroxidation","display_name":"Mitochondrial membrane lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c6acc8ba-a7ef-53de-b38c-a84f9cef7786","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-gpd2-loss-event","event_type":"biochemical_relationship","label":"Dependence on one pathway changed when the parallel defense was blocked.","description":"GPD2 deletion sensitized cancer cells to GPX4-inhibition-induced mitochondrial lipid peroxidation and ferroptosis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e9bb13ee-f238-51e6-9101-78ddfd11465c","slug":"gpx4","display_name":"GPX4","entity_type_key":"protein"},"role":"parallel_defense","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e3a468b0-08ac-57a3-8df4-942934b35b2a","slug":"gpd2","display_name":"Human mitochondrial glycerol-3-phosphate dehydrogenase / GPD2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b19acf65-87db-5ba1-bb18-a87e4b05af3d","slug":"mitochondrial-lipid-peroxidation","display_name":"Mitochondrial membrane lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/35749365.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8d8219ff3cd63697715c88c25a9e558315bcd95c25bbc38f76987544bfee7581\", \"start_char\": 0, \"end_char\": 1142, \"text_sha256\": \"8d8219ff3cd63697715c88c25a9e558315bcd95c25bbc38f76987544bfee7581\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Metabolomics, genetic deletion and tumor experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"G3P supply and GPD2/GPX4 loss","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preclinical mechanism; no evidence that glycerol or CoQ supplements treat cancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Cancer-cell and tumor models","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Dependence on one pathway changed when the parallel defense was blocked.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p35749365] A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. (2022). https://pubmed.ncbi.nlm.nih.gov/35749365/ DOI: 10.1073/pnas.2121987119","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Mitochondrial glycerol-phosphate oxidation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"4d5b7430-55ea-50f3-9843-082922791594","evidence_kind":"source_excerpt","locator":"Lines 866-877","start_line":866,"end_line":877,"excerpt":"### coq10-gpd2-loss\nGPD2 deletion sensitized cancer cells to GPX4-inhibition-induced mitochondrial lipid peroxidation and ferroptosis.\nCondition category: machinery_impairment\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Dependence on one pathway changed when the parallel defense was blocked.\norganism: Cancer-cell and tumor models\ntissue_or_cell_type: Mitochondrial glycerol-phosphate oxidation\nexperimental_model: Metabolomics, genetic deletion and tumor experiments\nlimitations: Preclinical mechanism; no evidence that glycerol or CoQ supplements treat cancer.\nexposure: G3P supply and GPD2/GPX4 loss\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/35749365.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8d8219ff3cd63697715c88c25a9e558315bcd95c25bbc38f76987544bfee7581\", \"start_char\": 0, \"end_char\": 1142, \"text_sha256\": \"8d8219ff3cd63697715c88c25a9e558315bcd95c25bbc38f76987544bfee7581\"}\n[coq10-p35749365] A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. (2022). https://pubmed.ncbi.nlm.nih.gov/35749365/ DOI: 10.1073/pnas.2121987119","model_system":"Metabolomics, genetic deletion and tumor experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p35749365] A ferroptosis defense mechanism mediated by glycerol-3-phosphate dehydrogenase 2 in mitochondria. (2022). https://pubmed.ncbi.nlm.nih.gov/35749365/ DOI: 10.1073/pnas.2121987119","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fc6c2f3b-14a3-59de-848e-ca1c02fee1df","stable_key":"import-3b5aff9b-4086-5574-bfb4-3ea49ba520d7","title":"Coenzyme Q10: biosynthesis, electron transfer, antioxidant recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"053f9a6f6c17321fa9fd271486d7f20a86a49b237424108de7dc8663372e73bf","revision_id":"028900ce-8ca4-5d13-8c86-6e327c071e64","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}