{"id":"8dfa81d1-19a0-5210-8fa6-be0b3091da9c","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-high-calcium","predicate":"increases","statement":"An 800 mg total caffeine gum regimen increased renal calcium clearance by 77%; changes correlated with sodium clearance and urine volume.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"4310e03f-468a-557a-8567-a0d2c2321c9c","mechanism_event_label":"High repeated exposure changed renal calcium clearance.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"c9b31fe4-a1d3-514c-96ee-bcce0414961f","slug":"renal-calcium-clearance","display_name":"Renal calcium clearance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4310e03f-468a-557a-8567-a0d2c2321c9c","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-high-calcium-event","event_type":"observed_relationship","label":"High repeated exposure changed renal calcium clearance.","description":"An 800 mg total caffeine gum regimen increased renal calcium clearance by 77%; 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no osteoporosis outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"High repeated exposure changed renal calcium clearance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of high-dose, short-term caffeine intake on the renal clearance of calcium, sodium and creatinine in healthy adults. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33852164/ · DOI 10.1111/bcp.14856","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ce6a6868-a29b-5a69-b12f-f29b7bcc6831","evidence_kind":"source_excerpt","locator":"Lines 356-362","start_line":356,"end_line":362,"excerpt":"## caf-high-calcium\nHigh repeated exposure changed renal calcium clearance.\nAn 800 mg total caffeine gum regimen increased renal calcium clearance by 77%; changes correlated with sodium clearance and urine volume.\nModel: Double-blind study, 12 caffeine and 12 placebo participants over six hours.\nLimitations: Proximal sodium-reabsorption inhibition was proposed from correlations, not directly measured; no osteoporosis outcome.\nEvidence access: Primary abstract\nThe effect of high-dose, short-term caffeine intake on the renal clearance of calcium, sodium and creatinine in healthy adults. · 2021 · https://pubmed.ncbi.nlm.nih.gov/33852164/ · DOI 10.1111/bcp.14856","model_system":"Double-blind study, 12 caffeine and 12 placebo participants over six hours.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"780d73d4abd45a0284d2cc0c646dbe8432ae347362891a4b98a19a61341a7325","revision_id":"f36ffb0a-d6df-522f-b783-5e30214b9e26","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}