{"id":"8def4179-577d-53e4-a1b6-16f8eb954696","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-zinc-deficiency-adh-decrease","predicate":"deficiency_reduces","statement":"Zinc-deficient rats had lower hepatic retinol-oxidizing ADH activity and greater hepatic vitamin A content.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3cea1c18-44e2-5768-a8e3-dbafe6bc4261","mechanism_event_label":"Zinc depletion changed retinoid handling in the liver.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"2a6cf817-aceb-50f3-b7a1-35e59b39eac8","slug":"hepatic-retinol-oxidizing-adh-activity","display_name":"Hepatic retinol-oxidizing ADH activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3cea1c18-44e2-5768-a8e3-dbafe6bc4261","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-zinc-deficiency-adh-decrease-event","event_type":"biochemical_relationship","label":"Zinc depletion changed retinoid handling in the liver.","description":"Zinc-deficient rats had lower hepatic retinol-oxidizing ADH activity and greater hepatic vitamin A content.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"148c57d8-c658-5769-89e8-1194cef2a782","slug":"retinol","display_name":"All-trans-retinol","entity_type_key":"small_molecule"},"role":"substrate","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"49c806c2-7041-5020-8b3b-fa04ffa122ac","slug":"zinc-ion","display_name":"Zinc(II) ion","entity_type_key":"ion"},"role":"nutrient_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2a6cf817-aceb-50f3-b7a1-35e59b39eac8","slug":"hepatic-retinol-oxidizing-adh-activity","display_name":"Hepatic retinol-oxidizing ADH activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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