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(1997). https://pubmed.ncbi.nlm.nih.gov/9143352/ DOI: 10.1006/abbi.1997.9964","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver enzyme preparations","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bfe9b17e-80ea-50cf-998b-7b8b3f6e1a96","evidence_kind":"source_excerpt","locator":"Lines 592-603","start_line":592,"end_line":603,"excerpt":"### coumarin-warfarin-inhibition-null\nWarfarin showed little or no CYP2A6 inhibition in this assay, with Ki above 200 micromolar.\nCondition category: normal\nnutrient_topic: Coumarin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Warfarin is a separate molecule with a different principal target.\norganism: Human\ntissue_or_cell_type: Liver enzyme preparations\nexperimental_model: Human microsomal and recombinant CYP2A6 inhibitor screen\nlimitations: In vitro inhibition thresholds are not demonstrated clinical interactions at food exposure.\nexposure: Coumarin 0.5–50 micromolar; 47 inhibitor/substrate probes\nevidence_span: {\"source_cache\": \"artifacts/coumarin-research/9143352.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"dca3f4253c2977d47070bb95696634ee2e06fa9a28a3d76ac9790ce695ed6f09\", \"start_char\": 0, \"end_char\": 2723, \"text_sha256\": \"dca3f4253c2977d47070bb95696634ee2e06fa9a28a3d76ac9790ce695ed6f09\"}\n[coumarin-p9143352] Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. 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