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unverified.","entity":null}],"evidence":[{"id":"01c7c120-a766-57d8-a2fa-542fb45031ec","evidence_kind":"source_excerpt","locator":"Lines 434-445","start_line":434,"end_line":445,"excerpt":"### renal-sgk1-loss-impairs-high-k-excretion\nRenal Sgk1 deletion blunted the early increase in urinary K excretion on high-K feeding, with hyperkalemia and reduced ENaC processing.\nCondition category: machinery_impairment\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Removing kidney SGK1 impairs the initial ability to clear a potassium load.\norganism: Mus musculus\ntissue_or_cell_type: Kidney tubules\nexperimental_model: Inducible tubular deletion; two-day high-K citrate diet\nlimitations: Excretion approached controls after longer adaptation; ROMK apical localization increased rather than decreased.\ncross_nutrient: Impaired ENaC sodium-channel adaptation accompanies defective K clearance.\nevidence_location: Results Figure 2; two-day versus five-day dietary comparison.\n[al-qusairi-2016-renal-sgk1] Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5005279/ DOI: 10.1152/ajprenal.00002.2016","model_system":"Inducible tubular deletion; two-day high-K citrate diet","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [al-qusairi-2016-renal-sgk1] Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC (2016). https://pmc.ncbi.nlm.nih.gov/articles/PMC5005279/ DOI: 10.1152/ajprenal.00002.2016","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}