{"id":"8d4025ba-8369-5cfd-b032-f1daeb2bc1e5","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-pparg-oxygen","predicate":"modulates","statement":"Microbiota-supported PPAR-gamma signaling drove mouse colonocytes toward beta-oxidation, limiting oxygen available to bacteria in the colonic lumen.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0ac9562a-2500-50d9-b624-1f5b4d0147c1","mechanism_event_label":"Colon-cell fuel use helped keep the neighboring microbial environment low in oxygen.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"44d55fd2-bde7-5bd1-91cd-c751ef642356","slug":"mouse-colonic-epithelial-oxygen-use","display_name":"Mouse colonic epithelial oxygen consumption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0ac9562a-2500-50d9-b624-1f5b4d0147c1","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-pparg-oxygen-event","event_type":"observed_relationship","label":"Colon-cell fuel use helped keep the neighboring microbial environment low in oxygen.","description":"Microbiota-supported PPAR-gamma signaling drove mouse colonocytes toward beta-oxidation, limiting oxygen available to bacteria in the colonic lumen.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"44d55fd2-bde7-5bd1-91cd-c751ef642356","slug":"mouse-colonic-epithelial-oxygen-use","display_name":"Mouse colonic epithelial oxygen consumption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse antibiotic, epithelial Pparg and microbial respiration experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Pathway dependence does not establish direct binding of butyrate to PPAR-gamma.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Colon-cell fuel use helped keep the neighboring microbial environment low in oxygen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microbiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28798125/ · DOI 10.1126/science.aam9949","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a6eafde8-ab46-5387-b1fd-b34b8666787e","evidence_kind":"source_excerpt","locator":"Lines 214-220","start_line":214,"end_line":220,"excerpt":"## butyrate-pparg-oxygen\nColon-cell fuel use helped keep the neighboring microbial environment low in oxygen.\nMicrobiota-supported PPAR-gamma signaling drove mouse colonocytes toward beta-oxidation, limiting oxygen available to bacteria in the colonic lumen.\nModel: Mouse antibiotic, epithelial Pparg and microbial respiration experiments.\nLimitations: Pathway dependence does not establish direct binding of butyrate to PPAR-gamma.\nEvidence access: Primary abstract\nMicrobiota-activated PPAR-γ signaling inhibits dysbiotic Enterobacteriaceae expansion. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28798125/ · DOI 10.1126/science.aam9949","model_system":"Mouse antibiotic, epithelial Pparg and microbial respiration experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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