{"id":"8d1cba12-0860-5d60-b25d-54af9d6bdffe","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-ra-b-cell-homing","predicate":"promotes","statement":"Dendritic-cell-derived RA conferred gut tropism on activated B cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"16e06480-3357-5dc2-80ca-04ffd3d5592f","mechanism_event_label":"RA helps route antibody-producing cell precursors to the intestine.","subject":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"object":{"id":"d2db3b94-a04e-55df-baa6-e97d911a1360","slug":"b-cell-gut-homing","display_name":"B-cell gut homing","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"16e06480-3357-5dc2-80ca-04ffd3d5592f","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-sig-ra-b-cell-homing-event","event_type":"biochemical_relationship","label":"RA helps route antibody-producing cell precursors to the intestine.","description":"Dendritic-cell-derived RA conferred gut tropism on activated B cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"nutrient-context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1d820845-9ea8-5049-a3f9-8c279bf0d36a","slug":"b-cell","display_name":"B cell","entity_type_key":"cell_type"},"role":"responding-cell","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9726a7f2-2470-585e-8cc6-b9fa67e6ae8f","slug":"gut-dendritic-cell","display_name":"Gut-associated dendritic cell","entity_type_key":"cell_type"},"role":"source","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"d2db3b94-a04e-55df-baa6-e97d911a1360","slug":"b-cell-gut-homing","display_name":"B-cell gut homing","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_locator","value_text":"Abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse B-cell/dendritic-cell systems and vitamin A-deficient mice.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Gut dendritic-cell-derived RA","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Gut tropism alone is not IgA secretion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"RA helps route antibody-producing cell precursors to the intestine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[va-mora-2006] Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells (2006). https://pubmed.ncbi.nlm.nih.gov/17110582/ DOI: 10.1126/science.1132742","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"B-cell cultures","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"807b6389-0e41-5a5a-bdd7-ba77b3fa406e","evidence_kind":"source_excerpt","locator":"Lines 1214-1225","start_line":1214,"end_line":1225,"excerpt":"### va-sig-ra-b-cell-homing\nDendritic-cell-derived RA conferred gut tropism on activated B cells.\nCondition category: normal\nnutrient_topic: Vitamin A research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: RA helps route antibody-producing cell precursors to the intestine.\norganism: Mus musculus\ntissue_or_cell_type: B-cell cultures\nexperimental_model: Mouse B-cell/dendritic-cell systems and vitamin A-deficient mice.\nlimitations: Gut tropism alone is not IgA secretion.\nevidence_locator: Abstract\nexposure: Gut dendritic-cell-derived RA\n[va-mora-2006] Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells (2006). https://pubmed.ncbi.nlm.nih.gov/17110582/ DOI: 10.1126/science.1132742","model_system":"Mouse B-cell/dendritic-cell systems and vitamin A-deficient mice.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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