{"id":"8d185167-e222-5d78-9222-743fcc48095f","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-phytate-calcium-retention","predicate":"dose_dependently_reduced","statement":"At the same ascending phytate-P additions, seven-day calcium retention was 31%, 28%, 27%, 26%, 22%, 19%, 14% and 11%; reduction was significant from 100 mg phytate-P in this study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"36772131-26a0-540d-8e41-80943862a52b","mechanism_event_label":"The same meal manipulation also reduced retained calcium.","subject":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"object":{"id":"a6b695d5-c38d-56be-916c-1888f6bc2739","slug":"whole-body-calcium-retention","display_name":"Whole-body calcium retention","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"36772131-26a0-540d-8e41-80943862a52b","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-phytate-calcium-retention-event","event_type":"observed_intervention","label":"The same meal manipulation also reduced retained calcium.","description":"At the same ascending phytate-P additions, seven-day calcium retention was 31%, 28%, 27%, 26%, 22%, 19%, 14% and 11%; reduction was significant from 100 mg phytate-P in this study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"retained_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"concurrently_measured_nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f64ba327-66e7-52b6-9424-7d7ec11acca4","slug":"phytic-acid","display_name":"Phytic acid / phytate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a6b695d5-c38d-56be-916c-1888f6bc2739","slug":"whole-body-calcium-retention","display_name":"Whole-body calcium retention","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Calcium (retained_nutrient); Zinc (concurrently_measured_nutrient)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/hallberg2006.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"3a8556f5e4076009ed9adbf018205c8a3b2d0aaae43cccc866dc6be0271451d4\", \"utf8_bytes\": 1603}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human dual-radioisotope meal study: 40 subjects, 105 meals","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Wheat-roll meals contained 3.1 mg zinc and 266 mg calcium; added sodium phytate supplied 0–250 mg phytate phosphorus.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Phytate-P mass is phosphorus mass, not total phytate mass. Seven-day calcium retention and zinc absorption are distinct endpoints; meal-specific significance levels are not universal thresholds.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The same meal manipulation also reduced retained calcium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-hallberg2006] Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate. (2006). https://pubmed.ncbi.nlm.nih.gov/16632176/ DOI: 10.1016/j.jtemb.2006.01.003","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal zinc absorption and whole-body calcium retention","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9aef2c58-53d3-5363-aaf8-dc1cccf40144","evidence_kind":"source_excerpt","locator":"Lines 1302-1315","start_line":1302,"end_line":1315,"excerpt":"### zn-clin-phytate-calcium-retention\nAt the same ascending phytate-P additions, seven-day calcium retention was 31%, 28%, 27%, 26%, 22%, 19%, 14% and 11%; reduction was significant from 100 mg phytate-P in this study.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The same meal manipulation also reduced retained calcium.\norganism: Homo sapiens\ntissue_or_cell_type: Intestinal zinc absorption and whole-body calcium retention\nexperimental_model: Human dual-radioisotope meal study: 40 subjects, 105 meals\nlimitations: Phytate-P mass is phosphorus mass, not total phytate mass. Seven-day calcium retention and zinc absorption are distinct endpoints; meal-specific significance levels are not universal thresholds.\nexposure: Wheat-roll meals contained 3.1 mg zinc and 266 mg calcium; added sodium phytate supplied 0–250 mg phytate phosphorus.\ncross_nutrient: Calcium (retained_nutrient); Zinc (concurrently_measured_nutrient)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/hallberg2006.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"3a8556f5e4076009ed9adbf018205c8a3b2d0aaae43cccc866dc6be0271451d4\", \"utf8_bytes\": 1603}\n[zn-clin-hallberg2006] Absorption of zinc and retention of calcium: dose-dependent inhibition by phytate. 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