{"id":"8ca83e57-3a7e-5b7d-9ee2-92b230317094","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:pooled-randomized-trials-show-a-small-blood-pressure-reduction","predicate":"reduces","statement":"Across six randomized trials with 546 participants, pooled systolic blood pressure fell by 3.45 mmHg and diastolic by 2.32 mmHg against placebo.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2fce0c8d-6f7f-5265-84a5-cad06af4f613","mechanism_event_label":"Across six randomized trials with 546 participants, pooled systolic blood pressure fell by 3.45 mmHg and diastolic by 2.32 mmHg against placebo.","subject":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2fce0c8d-6f7f-5265-84a5-cad06af4f613","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:pooled-randomized-trials-show-a-small-blood-pressure-reduction-event","event_type":"observed_intervention","label":"Across six randomized trials with 546 participants, pooled systolic blood pressure fell by 3.45 mmHg and diastolic by 2.32 mmHg against placebo.","description":"Arterial blood pressure","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e8eb9bb4-3c6f-5e96-a968-a6d1fece71e7","slug":"nattokinase-supplement","display_name":"Commercial nattokinase supplement, composition study-specific","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Trial durations differ","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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The pooled estimate inherits the industry affiliation of several component trials and does not include the three-year randomized trial that found no blood-pressure effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human, systematic review and meta-analysis of randomized controlled trials","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Across six randomized trials with 546 participants, pooled systolic blood pressure fell by 3.45 mmHg and diastolic by 2.32 mmHg against placebo.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Nattokinase Supplementation and Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 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Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. 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