{"id":"8c91ca11-3ffb-587d-bf5d-999f54bc1d26","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-prediabetes-null","predicate":"did_not_improve","statement":"Neither tested dose improved glucose, insulin or HOMA-IR compared with placebo after six months; secondary outcomes also did not improve.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"e761c8de-fdb4-5392-9a0b-13f42475f607","mechanism_event_label":"The supplement did not improve the measured insulin-resistance outcomes in this at-risk group.","subject":{"id":"89d5d39c-2663-5e0c-8eae-562a5b25a47d","slug":"chromium-iii-picolinate","display_name":"Chromium(III) picolinate / CrPic","entity_type_key":"chemical_species"},"object":{"id":"63223a9d-b872-57dd-b4b9-2085d2db023f","slug":"homa-insulin-resistance","display_name":"HOMA-IR estimate of insulin resistance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e761c8de-fdb4-5392-9a0b-13f42475f607","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-prediabetes-null-event","event_type":"observed_intervention","label":"The supplement did not improve the measured insulin-resistance outcomes in this at-risk group.","description":"Neither tested dose improved glucose, insulin or HOMA-IR compared with placebo after six months; secondary outcomes also did not improve.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89d5d39c-2663-5e0c-8eae-562a5b25a47d","slug":"chromium-iii-picolinate","display_name":"Chromium(III) picolinate / CrPic","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"63223a9d-b872-57dd-b4b9-2085d2db023f","slug":"homa-insulin-resistance","display_name":"HOMA-IR estimate of insulin resistance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/20634174.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8a4617886df8215ff55fd78eac2a60d4e63ed726da4f1f1a9167fb9c41ceae26\", \"start_char\": 0, \"end_char\": 1529, \"text_sha256\": \"8a4617886df8215ff55fd78eac2a60d4e63ed726da4f1f1a9167fb9c41ceae26\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind modified crossover trial; 59 enrolled","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Six-month sequences of 500 or 1,000 µg/day chromium picolinate versus placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"At-risk population rather than established diabetes; no demonstrated prevention effect. Exposure does not establish the participant’s nutritional chromium status.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human adults at high risk for type 2 diabetes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The supplement did not improve the measured insulin-resistance outcomes in this at-risk group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p20634174] Chromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitus. (2011). https://pubmed.ncbi.nlm.nih.gov/20634174/ DOI: 10.4158/ep10131.or","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Glucose, insulin, HOMA-IR and secondary cardiometabolic endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"74ce7759-5a20-5c1b-9965-d936c0bbfde4","evidence_kind":"source_excerpt","locator":"Lines 1108-1119","start_line":1108,"end_line":1119,"excerpt":"### chromium-prediabetes-null\nNeither tested dose improved glucose, insulin or HOMA-IR compared with placebo after six months; secondary outcomes also did not improve.\nCondition category: normal\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The supplement did not improve the measured insulin-resistance outcomes in this at-risk group.\norganism: Human adults at high risk for type 2 diabetes\ntissue_or_cell_type: Glucose, insulin, HOMA-IR and secondary cardiometabolic endpoints\nexperimental_model: Randomized double-blind modified crossover trial; 59 enrolled\nlimitations: At-risk population rather than established diabetes; no demonstrated prevention effect. Exposure does not establish the participant’s nutritional chromium status.\nexposure: Six-month sequences of 500 or 1,000 µg/day chromium picolinate versus placebo\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/20634174.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"8a4617886df8215ff55fd78eac2a60d4e63ed726da4f1f1a9167fb9c41ceae26\", \"start_char\": 0, \"end_char\": 1529, \"text_sha256\": \"8a4617886df8215ff55fd78eac2a60d4e63ed726da4f1f1a9167fb9c41ceae26\"}\n[chromium-p20634174] Chromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitus. (2011). https://pubmed.ncbi.nlm.nih.gov/20634174/ DOI: 10.4158/ep10131.or","model_system":"Randomized double-blind modified crossover trial; 59 enrolled","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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