{"id":"8c726327-c31e-5630-8cd7-6150fa228f56","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-human-bat-null","predicate":"modulates","statement":"Oral sodium butyrate did not significantly increase brown-adipose glucose uptake in either lean or metabolic-syndrome men in the pilot.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"100e515c-26c9-5e26-b5df-1f0db24bf6bd","mechanism_event_label":"The expected brown-fat response was not detected.","subject":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"object":{"id":"333641cf-dff9-5048-a171-f2242160c3e4","slug":"human-butyrate-bat-activity","display_name":"Human brown-adipose glucose uptake after oral butyrate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"100e515c-26c9-5e26-b5df-1f0db24bf6bd","stable_key":"104835a3-b891-5dc4-a6bb-42ab7c6f96c4:butyrate-human-bat-null-event","event_type":"observed_relationship","label":"The expected brown-fat response was not detected.","description":"Oral sodium butyrate did not significantly increase brown-adipose glucose uptake in either lean or metabolic-syndrome men in the pilot.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e7428a7f-d35a-5406-9904-a88984814833","slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"333641cf-dff9-5048-a171-f2242160c3e4","slug":"human-butyrate-bat-activity","display_name":"Human brown-adipose glucose uptake after oral butyrate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4baf6011-dcc4-5a69-9c77-a21de6060383","slug":"sodium-butyrate","display_name":"Sodium butyrate","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human FDG-PET/CT before/after measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"FDG uptake is a particular endpoint, not a complete assay of all thermogenesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Butyrate collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"butyrate","display_name":"Butyrate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The expected brown-fat response was not detected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29799027/ · DOI 10.1038/s41424-018-0025-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"168a7dac-f334-532b-b149-2f351f9a178d","evidence_kind":"source_excerpt","locator":"Lines 574-580","start_line":574,"end_line":580,"excerpt":"## butyrate-human-bat-null\nThe expected brown-fat response was not detected.\nOral sodium butyrate did not significantly increase brown-adipose glucose uptake in either lean or metabolic-syndrome men in the pilot.\nModel: Human FDG-PET/CT before/after measurements.\nLimitations: FDG uptake is a particular endpoint, not a complete assay of all thermogenesis.\nEvidence access: Primary abstract\nDifferential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29799027/ · DOI 10.1038/s41424-018-0025-4","model_system":"Human FDG-PET/CT before/after measurements.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"33205bb8-dcbe-5d2c-afca-86075d7748d1","stable_key":"import-104835a3-b891-5dc4-a6bb-42ab7c6f96c4","title":"Butyrate: microbial production, fuel use, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a1253eb4426fc45d7b7c113028aa4ba2e9f89a9653272f3795437fc222bad558","revision_id":"c2320e65-a252-57a9-8838-7abf3d23400e","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}