{"id":"8c6ec9e5-ac89-577b-b175-cb9597f5c5c7","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-pparg-corneal","predicate":"mediates_luteolin_response","statement":"Luteolin reduced IL-8 release and restored electrical resistance in hypertonic human corneal epithelial cultures through a PPAR gamma-dependent response.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c70bfe97-45ab-5772-ac93-6b1fed63143e","mechanism_event_label":"An eye-surface model links inflammation and barrier function.","subject":{"id":"7f456e18-fabc-532d-bbfe-cd3a8cf1b348","slug":"pparg","display_name":"Human PPAR gamma / PPARG","entity_type_key":"protein"},"object":{"id":"8cbfdb2b-1e45-5fd0-a29e-a8bd5f802770","slug":"human-corneal-hypertonic-response","display_name":"Human corneal epithelial hypertonic inflammatory/barrier response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c70bfe97-45ab-5772-ac93-6b1fed63143e","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-pparg-corneal-event","event_type":"observed_relationship","label":"An eye-surface model links inflammation and barrier function.","description":"Luteolin reduced IL-8 release and restored electrical resistance in hypertonic human corneal epithelial cultures through a PPAR gamma-dependent response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7f456e18-fabc-532d-bbfe-cd3a8cf1b348","slug":"pparg","display_name":"Human PPAR gamma / PPARG","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8cbfdb2b-1e45-5fd0-a29e-a8bd5f802770","slug":"human-corneal-hypertonic-response","display_name":"Human corneal epithelial hypertonic inflammatory/barrier response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human corneal epithelial cell culture.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not an oral dry-eye treatment trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"An eye-surface model links inflammation and barrier function.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Mode of peroxisome proliferator-activated receptor γ activation by luteolin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22391103/ · DOI 10.1124/mol.111.076216","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8f1f9428-8937-5992-9342-36dfb7c666f1","evidence_kind":"source_excerpt","locator":"Lines 380-386","start_line":380,"end_line":386,"excerpt":"## luteolin-pparg-corneal\nAn eye-surface model links inflammation and barrier function.\nLuteolin reduced IL-8 release and restored electrical resistance in hypertonic human corneal epithelial cultures through a PPAR gamma-dependent response.\nModel: Human corneal epithelial cell culture.\nLimitations: Not an oral dry-eye treatment trial.\nEvidence access: Primary abstract\nMode of peroxisome proliferator-activated receptor γ activation by luteolin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22391103/ · DOI 10.1124/mol.111.076216","model_system":"Human corneal epithelial cell culture.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}