{"id":"8c63e015-e437-517d-9071-b6a388272f75","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-platelet-calcium","predicate":"reduces","statement":"Luteolin reduced collagen/convulxin-induced calcium responses and secretion in washed human platelets.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"98659599-38f1-579c-8850-bd67e33fa3a1","mechanism_event_label":"Calcium signaling connects receptor activation to platelet release.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"ffd6c2f5-1dfa-53a7-92ee-2824da6840a6","slug":"human-gpvi-platelet-calcium-response","display_name":"Human GPVI-triggered platelet calcium response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"98659599-38f1-579c-8850-bd67e33fa3a1","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-platelet-calcium-event","event_type":"observed_relationship","label":"Calcium signaling connects receptor activation to platelet release.","description":"Luteolin reduced collagen/convulxin-induced calcium responses and secretion in washed human platelets.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ffd6c2f5-1dfa-53a7-92ee-2824da6840a6","slug":"human-gpvi-platelet-calcium-response","display_name":"Human GPVI-triggered platelet calcium response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"d272a278-9216-5556-a41c-56fbb2cf3e8f","slug":"gp6","display_name":"Human platelet glycoprotein VI / GP6","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Washed human platelets, 2.5–25 micromolar range in activation assays.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not systemic calcium depletion or evidence of human bleeding safety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Calcium signaling connects receptor activation to platelet release.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Luteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis. · 2023 · https://pubmed.ncbi.nlm.nih.gov/38026984/ · DOI 10.3389/fphar.2023.1255069","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c3cfd784-acc8-5b77-9c49-517ee2623920","evidence_kind":"source_excerpt","locator":"Lines 436-442","start_line":436,"end_line":442,"excerpt":"## luteolin-platelet-calcium\nCalcium signaling connects receptor activation to platelet release.\nLuteolin reduced collagen/convulxin-induced calcium responses and secretion in washed human platelets.\nModel: Washed human platelets, 2.5–25 micromolar range in activation assays.\nLimitations: Not systemic calcium depletion or evidence of human bleeding safety.\nEvidence access: Primary full text\nLuteolin inhibits GPVI-mediated platelet activation, oxidative stress, and thrombosis. · 2023 · https://pubmed.ncbi.nlm.nih.gov/38026984/ · DOI 10.3389/fphar.2023.1255069","model_system":"Washed human platelets, 2.5–25 micromolar range in activation assays.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}