{"id":"8c433083-9cf6-52c8-b0e6-3b00764b3fa0","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-il4i1-route","predicate":"generates_ahr_activating_products","statement":"IL4I1 generated indole metabolites and kynurenic acid that activated AHR in the cancer study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d6042003-8368-571b-9629-1cb8d4bad1db","mechanism_event_label":"Another enzyme can feed the same receptor through different metabolites.","subject":{"id":"acbbf0c2-4c0f-5fc6-86ac-e817647db149","slug":"il4i1","display_name":"Human interleukin-4-induced protein 1 / IL4I1","entity_type_key":"protein"},"object":{"id":"757ea2d0-1c8e-5453-a721-4a3a3443a383","slug":"ahr","display_name":"Human aryl hydrocarbon receptor / AHR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"d6042003-8368-571b-9629-1cb8d4bad1db","stable_key":"584c58f5-ab9f-53f3-97a9-55783db943b0:tryptophan-il4i1-route-event","event_type":"observed_relationship","label":"Another enzyme can feed the same receptor through different metabolites.","description":"IL4I1 generated indole metabolites and kynurenic acid that activated AHR in the cancer study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"acbbf0c2-4c0f-5fc6-86ac-e817647db149","slug":"il4i1","display_name":"Human interleukin-4-induced protein 1 / IL4I1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"757ea2d0-1c8e-5453-a721-4a3a3443a383","slug":"ahr","display_name":"Human aryl hydrocarbon receptor / AHR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"769339cb-213b-559e-acc0-07ed00368b94","slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6a123629-5a43-57ef-bba0-c429005ab5b3","slug":"kynurenic-acid","display_name":"Kynurenic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human cancer/biochemical work with separate mouse CLL experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This abstract groups several products; their individual concentrations and relative causal contributions are not resolved here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Tryptophan collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-tryptophan","display_name":"L-Tryptophan","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Another enzyme can feed the same receptor through different metabolites.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32818467/ · DOI 10.1016/j.cell.2020.07.038","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"108514ce-9c44-5db9-96e3-f0ad2c8d9bd3","evidence_kind":"source_excerpt","locator":"Lines 450-456","start_line":450,"end_line":456,"excerpt":"## tryptophan-il4i1-route\nAnother enzyme can feed the same receptor through different metabolites.\nIL4I1 generated indole metabolites and kynurenic acid that activated AHR in the cancer study.\nModel: Human cancer/biochemical work with separate mouse CLL experiments.\nLimitations: This abstract groups several products; their individual concentrations and relative causal contributions are not resolved here.\nEvidence access: Primary abstract\nIL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32818467/ · DOI 10.1016/j.cell.2020.07.038","model_system":"Human cancer/biochemical work with separate mouse CLL experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"73f9d3e7-fdc9-5418-8f3c-f4ef145f6efa","stable_key":"import-584c58f5-ab9f-53f3-97a9-55783db943b0","title":"Tryptophan: transport, protein synthesis, neuroactive metabolites, NAD and microbial pathways (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"7dfd20063b91900cb5c6ad675e3e675b7e25ef0fb8304eabac6f263cc5518284","revision_id":"bfafd789-fdf5-521f-bd28-c662e01ec1ea","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}