{"id":"8c16029a-b2c1-5b14-9627-db2a606e5a6c","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-sleep-rat-scn","predicate":"modulates_tested","statement":"Glycine increased cutaneous blood flow and promoted sleep in the rat experiments; SCN ablation abolished the reported sleep-promoting and hypothermic responses.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d41313a0-6a9a-5535-9e3a-d38332734525","mechanism_event_label":"A brain circuit connected the amino-acid intervention with body heat loss.","subject":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"object":{"id":"b6380207-6615-519a-96a3-4dcc8e4155d6","slug":"rat-scn-glycine-heat-loss","display_name":"SCN-dependent heat loss and sleep response in rats","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d41313a0-6a9a-5535-9e3a-d38332734525","stable_key":"507ed066-fd6d-5722-9223-97b66302e7e3:glycine-sleep-rat-scn-event","event_type":"observed_relationship","label":"A brain circuit connected the amino-acid intervention with body heat loss.","description":"Glycine increased cutaneous blood flow and promoted sleep in the rat experiments; SCN ablation abolished the reported sleep-promoting and hypothermic responses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b6380207-6615-519a-96a3-4dcc8e4155d6","slug":"rat-scn-glycine-heat-loss","display_name":"SCN-dependent heat loss and sleep response in rats","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat oral, intracerebral and SCN-ablation experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The routes are not interchangeable; abstract-level extraction does not establish the human mediation mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glycine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A brain circuit connected the amino-acid intervention with body heat loss.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25533534/ · DOI 10.1038/npp.2014.326","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"909d411e-16fb-5fb4-b96e-08bce5ae44b0","evidence_kind":"source_excerpt","locator":"Lines 410-416","start_line":410,"end_line":416,"excerpt":"## glycine-sleep-rat-scn\nA brain circuit connected the amino-acid intervention with body heat loss.\nGlycine increased cutaneous blood flow and promoted sleep in the rat experiments; SCN ablation abolished the reported sleep-promoting and hypothermic responses.\nModel: Rat oral, intracerebral and SCN-ablation experiments.\nLimitations: The routes are not interchangeable; abstract-level extraction does not establish the human mediation mechanism.\nEvidence access: Primary abstract\nThe sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25533534/ · DOI 10.1038/npp.2014.326","model_system":"Rat oral, intracerebral and SCN-ablation experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7b2859d8-e2bf-51e7-8e32-0715c10cbc49","stable_key":"import-507ed066-fd6d-5722-9223-97b66302e7e3","title":"Glycine: supply, one-carbon allocation, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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