{"id":"8bc102b4-2a89-5a0b-b120-bb1157de75c5","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-rat-anxiety-null","predicate":"no_detected_change_in_recorded_comparison","statement":"Intraperitoneal apigenin reduced rat locomotion but did not produce an anxiolytic effect in that study.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"792d56f8-ed9b-5e42-a941-316ecb8576a9","mechanism_event_label":"Intraperitoneal apigenin reduced rat locomotion but did not produce an anxiolytic effect in that study.","subject":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"object":{"id":"d33085ee-32cc-560a-a2d3-9cb0c85588bd","slug":"api-rat-anxiety-assay","display_name":"Rat anxiety behavior in the 2000 apigenin study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"792d56f8-ed9b-5e42-a941-316ecb8576a9","stable_key":"ff370329-68a3-573d-96ee-597de78a3967:api-rat-anxiety-null-event","event_type":"experimental_observation","label":"Intraperitoneal apigenin reduced rat locomotion but did not produce an anxiolytic effect in that study.","description":"### api-rat-anxiety-null\n\nIntraperitoneal apigenin reduced rat locomotion but did not produce an anxiolytic effect in that study.\nThe locomotor effect was not blocked by flumazenil. Earlier mouse plus-maze findings used a different experimental setting.\nModel and exposure: Rat behavioral experiments; dose not independently extracted from abstract.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. | 2000 | https://pubmed.ncbi.nlm.nih.gov/10751547/ | https://doi.org/10.1016/s0006-2952(00)00264-1 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4425961f-4764-56d3-9887-87e47749379b","slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"Apigenin","sequence_order":0,"notes":""},{"entity":{"id":"d33085ee-32cc-560a-a2d3-9cb0c85588bd","slug":"api-rat-anxiety-assay","display_name":"Rat anxiety behavior in the 2000 apigenin study","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Apigenin\", \"comparator\": \"Vehicle anxiety-assay controls\", \"endpoint\": \"Intraperitoneal apigenin reduced rat locomotion but did not produce an anxiolytic effect in that study.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; recorded from source.","entity":null},{"dimension":"experimental_model","value_text":"Rat behavioral experiments; dose not independently extracted from abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Recorded from source with stated access limits; ungraded, not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Apigenin collection; exact intervention and molecular form govern interpretation.","comparator":null,"unit":null,"notes":"","entity":{"slug":"apigenin","display_name":"Apigenin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Intraperitoneal apigenin reduced rat locomotion but did not produce an anxiolytic effect in that study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. | https://pubmed.ncbi.nlm.nih.gov/10751547/ | https://doi.org/10.1016/s0006-2952(00)00264-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference api-rat-anxiety-null; The locomotor effect was not blocked by flumazenil. Earlier mouse plus-maze findings used a different experimental setting.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2ee89045-6b0b-5439-9c91-08530f57c8d0","evidence_kind":"source_excerpt","locator":"Lines 796-802","start_line":796,"end_line":802,"excerpt":"### api-rat-anxiety-null\n\nIntraperitoneal apigenin reduced rat locomotion but did not produce an anxiolytic effect in that study.\nThe locomotor effect was not blocked by flumazenil. Earlier mouse plus-maze findings used a different experimental setting.\nModel and exposure: Rat behavioral experiments; dose not independently extracted from abstract.\nLimitations: Limited to the recorded preparation, model, exposure and endpoint. Does not establish a human dietary deficiency, clinical benefit or unique molecular mediation.\nReference: Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. | 2000 | https://pubmed.ncbi.nlm.nih.gov/10751547/ | https://doi.org/10.1016/s0006-2952(00)00264-1 | Access: Indexed primary abstract/metadata only; unextracted doses, figures and methods remain unknown.","model_system":"Rat behavioral experiments; dose not independently extracted from abstract.","directness":"reported_statement","verification_status":"source_recorded","notes":"Original paraphrase in the retained reviewed reference, not a verbatim primary-paper quotation. Access level is explicit.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"54eac90b-add1-5f56-9036-d900307c5697","stable_key":"import-ff370329-68a3-573d-96ee-597de78a3967","title":"Apigenin: detailed mechanisms of action (reviewed 10 October 2026)","document_type":"imported_text","citation_label":"AI-assisted original curation of primary studies; claim-local access and experimental limitations stated. Includes original-draft correction history. No independent replication claimed.","file_path":"","sha256":"ede6e5c6b91d66b66844f2ff667a7f8303d9ac1281f15dc09db703f7de4da942","revision_id":"b41a39a2-0197-549c-97a5-1765e6696931","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}