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Expression changes are not demonstrated neurogenesis in adult humans; reporter experiments do not prove every causal link.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Theanine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"theanine","display_name":"L-Theanine","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Embryonic rat neural progenitors; mouse P19 reporter cells in separate assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The balance between two developmental fates changed in this model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[theanine-p25957749] Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine. (2016). https://pubmed.ncbi.nlm.nih.gov/25957749/ DOI: 10.1007/s11064-015-1591-4","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Progenitor proliferation and lineage commitment","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"826cabe2-78ec-5ed3-a0d3-503968f6a7ee","evidence_kind":"source_excerpt","locator":"Lines 354-365","start_line":354,"end_line":365,"excerpt":"### theanine-neuronal-lineage\nPrior theanine exposure favored neuronal lineage commitment while reducing astroglial specification in the cultured progenitors.\nCondition category: normal\nnutrient_topic: L-Theanine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The balance between two developmental fates changed in this model.\norganism: Embryonic rat neural progenitors; mouse P19 reporter cells in separate assays\ntissue_or_cell_type: Progenitor proliferation and lineage commitment\nexperimental_model: Sustained exposure, neurospheres and promoter-reporter experiments\nlimitations: Immature cells differ from mature neurons/astroglia. Expression changes are not demonstrated neurogenesis in adult humans; reporter experiments do not prove every causal link.\nexposure: Theanine 1-100 micromolar; sustained culture exposure\nevidence_span: {\"source_cache\": \"artifacts/theanine-research/25957749.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"7ebc4fc37f26e19c2d7fb13442e263182e628beda7286839f7d0de0906d59f8e\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"7ebc4fc37f26e19c2d7fb13442e263182e628beda7286839f7d0de0906d59f8e\"}\n[theanine-p25957749] Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine. 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