{"id":"8b51c16d-49f5-5c89-83a4-cc11d6568278","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-depletion-tnf","predicate":"restriction_reduced","statement":"Experimental human zinc restriction reduced tumor necrosis factor alpha production, contributing to the selective decline in the tested TH1-associated cytokine response.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8f9a2191-9fd0-55c7-84ef-cd43a729f2aa","mechanism_event_label":"Zinc shortage reduced tumor necrosis factor alpha production in the tested immune cells.","subject":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"object":{"id":"84e39b5d-d326-56e5-81ff-2f43765f39d8","slug":"t-cell-tnf-production","display_name":"T-cell tumor necrosis factor production","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8f9a2191-9fd0-55c7-84ef-cd43a729f2aa","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-depletion-tnf-event","event_type":"observed_intervention","label":"Zinc shortage reduced tumor necrosis factor alpha production in the tested immune cells.","description":"Experimental human zinc restriction reduced tumor necrosis factor alpha production, contributing to the selective decline in the tested TH1-associated cytokine response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"600d5b09-e092-5146-af1e-2510cf17bac6","slug":"tnf","display_name":"Tumor necrosis factor","entity_type_key":"cytokine"},"role":"measured_cytokine","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0429f0ff-c033-514b-9a4f-6f0f83268095","slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"84e39b5d-d326-56e5-81ff-2f43765f39d8","slug":"t-cell-tnf-production","display_name":"T-cell tumor necrosis factor production","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"Tumor necrosis factor (measured_cytokine)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/beck1997.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"f731be20460b3ded18a253c1d1595c48849db9c09ef164f8a7d03a552e5619dd\", \"utf8_bytes\": 1106}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Experimental dietary zinc restriction and repletion in humans","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Baseline, end of zinc restriction, and following repletion were assessed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Indexed abstract only; no sample size, intake, duration, assay stimulus or repletion effect size is invented. Changes in selected cytokines do not quantify overall infection risk.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Zinc shortage reduced tumor necrosis factor alpha production in the tested immune cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-beck1997] Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. (1997). https://pubmed.ncbi.nlm.nih.gov/9227444/ DOI: 10.1152/ajpendo.1997.272.6.e1002","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"T lymphocytes and cytokine production","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"89352384-0815-5a64-a1cc-9ab39961a8c7","evidence_kind":"source_excerpt","locator":"Lines 1377-1390","start_line":1377,"end_line":1390,"excerpt":"### zn-clin-depletion-tnf\nExperimental human zinc restriction reduced tumor necrosis factor alpha production, contributing to the selective decline in the tested TH1-associated cytokine response.\nCondition category: nutrient_deficiency\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Zinc shortage reduced tumor necrosis factor alpha production in the tested immune cells.\norganism: Homo sapiens\ntissue_or_cell_type: T lymphocytes and cytokine production\nexperimental_model: Experimental dietary zinc restriction and repletion in humans\nlimitations: Indexed abstract only; no sample size, intake, duration, assay stimulus or repletion effect size is invented. Changes in selected cytokines do not quantify overall infection risk.\nexposure: Baseline, end of zinc restriction, and following repletion were assessed.\ncross_nutrient: Tumor necrosis factor (measured_cytokine)\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/beck1997.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"f731be20460b3ded18a253c1d1595c48849db9c09ef164f8a7d03a552e5619dd\", \"utf8_bytes\": 1106}\n[zn-clin-beck1997] Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. (1997). https://pubmed.ncbi.nlm.nih.gov/9227444/ DOI: 10.1152/ajpendo.1997.272.6.e1002","model_system":"Experimental dietary zinc restriction and repletion in humans","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [zn-clin-beck1997] Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. (1997). https://pubmed.ncbi.nlm.nih.gov/9227444/ DOI: 10.1152/ajpendo.1997.272.6.e1002","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c5ee0fee-ce5c-58de-905a-10fb0ea0723c","stable_key":"import-6d38d43e-01e4-5641-93be-65654271e242","title":"Zinc: transport, enzyme loading, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2e731dd54477ec1254e97df3323e1208d38f1375effed19252e71ab4f600d13a","revision_id":"c72258b9-ac09-5408-9d44-a921ad1f96a3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}