{"id":"8b41b057-919c-552b-9d4e-5c91f8396e4a","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-microcarrier-vegf","predicate":"enhances","statement":"Microcarriers releasing silicon and loaded VEGF increased endothelial migration and tubular networking.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9ba4a91d-4f71-5550-9e76-312f2c21f450","mechanism_event_label":"A tested growth-factor combination promoted vascular-cell behavior.","subject":{"id":"991b0aee-d3b1-5fdc-bb9b-dd49d00b0bd2","slug":"mesoporous-silica-microcarriers","display_name":"Mesoporous silica microcarriers","entity_type_key":"chemical_species"},"object":{"id":"e999f985-9ee4-5a66-9100-24c8df52a0ed","slug":"human-silica-vegf-angiogenesis","display_name":"Endothelial response to silicon/VEGF microcarriers","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9ba4a91d-4f71-5550-9e76-312f2c21f450","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-microcarrier-vegf-event","event_type":"observed_relationship","label":"A tested growth-factor combination promoted vascular-cell behavior.","description":"Microcarriers releasing silicon and loaded VEGF increased endothelial migration and tubular networking.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"991b0aee-d3b1-5fdc-bb9b-dd49d00b0bd2","slug":"mesoporous-silica-microcarriers","display_name":"Mesoporous silica microcarriers","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e999f985-9ee4-5a66-9100-24c8df52a0ed","slug":"human-silica-vegf-angiogenesis","display_name":"Endothelial response to silicon/VEGF microcarriers","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f4e8cf70-ed41-55d8-8299-62e01c83ab2d","slug":"human-vegfa","display_name":"Human VEGFA","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"22b3e241-94b0-55fd-a233-c63af92520d8","slug":"hif1a","display_name":"HIF-1 alpha","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human HUVECs; engineered local-release formulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not evidence of oral silica/VEGF supplementation or a universal synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A tested growth-factor combination promoted vascular-cell behavior.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Promoting angiogenesis with mesoporous microcarriers through a synergistic action of delivered silicon ion and VEGF. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27918936/ · DOI 10.1016/j.biomaterials.2016.11.053","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c9532c95-3bcc-5382-bf14-25142e15bf78","evidence_kind":"source_excerpt","locator":"Lines 280-286","start_line":280,"end_line":286,"excerpt":"## silica-microcarrier-vegf\nA tested growth-factor combination promoted vascular-cell behavior.\nMicrocarriers releasing silicon and loaded VEGF increased endothelial migration and tubular networking.\nModel: Human HUVECs; engineered local-release formulation.\nLimitations: Not evidence of oral silica/VEGF supplementation or a universal synergy.\nEvidence access: Primary abstract\nPromoting angiogenesis with mesoporous microcarriers through a synergistic action of delivered silicon ion and VEGF. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27918936/ · DOI 10.1016/j.biomaterials.2016.11.053","model_system":"Human HUVECs; engineered local-release formulation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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