{"id":"8b39ad6b-e319-55e7-a6d5-51d7b0e1e760","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-tumor-marker-limit","predicate":"inversely_associated_with","statement":"Aspartate abundance in primary human tumor samples negatively correlated with hypoxia-marker expression.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"46cedb48-062c-53f9-9c8c-790bad279fba","mechanism_event_label":"Human tumor measurements were consistent with the oxygen-related mechanism.","subject":{"id":"25e6e198-0fdf-50ef-89d7-dfb6b6b39c80","slug":"human-tumor-hypoxia-markers","display_name":"Hypoxia-marker expression in primary human tumors","entity_type_key":"cellular_process"},"object":{"id":"70f0d45d-d7ca-5129-859b-8ed8ca84c16d","slug":"human-tumor-aspartate-pool","display_name":"Aspartate pool in sampled primary human tumors","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"46cedb48-062c-53f9-9c8c-790bad279fba","stable_key":"e37461ea-ea5d-5e2c-8091-138305f6dd70:l-aspartate-tumor-marker-limit-event","event_type":"observed_relationship","label":"Human tumor measurements were consistent with the oxygen-related mechanism.","description":"Aspartate abundance in primary human tumor samples negatively correlated with hypoxia-marker expression.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"25e6e198-0fdf-50ef-89d7-dfb6b6b39c80","slug":"human-tumor-hypoxia-markers","display_name":"Hypoxia-marker expression in primary human tumors","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"70f0d45d-d7ca-5129-859b-8ed8ca84c16d","slug":"human-tumor-aspartate-pool","display_name":"Aspartate pool in sampled primary human tumors","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0a0923d3-72b7-5d6a-bf3a-5a7a3071a09b","slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human tumor metabolite and marker analysis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Correlation alone cannot establish causal direction or a universal tissue threshold. Correction record: The 2018 author correction added a missing competing-interests statement declaring no competing interests; no mechanism or data change was stated. PMID 30089842; DOI 10.1038/s41556-018-0184-2. https://pubmed.ncbi.nlm.nih.gov/30089842/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-aspartate","display_name":"L-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Human tumor measurements were consistent with the oxygen-related mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29941933/ · DOI 10.1038/s41556-018-0118-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f419bbe4-144c-5437-b9ab-17b273b200ae","evidence_kind":"source_excerpt","locator":"Lines 90-96","start_line":90,"end_line":96,"excerpt":"## l-aspartate-tumor-marker-limit\nHuman tumor measurements were consistent with the oxygen-related mechanism.\nAspartate abundance in primary human tumor samples negatively correlated with hypoxia-marker expression.\nModel: Human tumor metabolite and marker analysis.\nLimitations: Correlation alone cannot establish causal direction or a universal tissue threshold. Correction record: The 2018 author correction added a missing competing-interests statement declaring no competing interests; no mechanism or data change was stated. PMID 30089842; DOI 10.1038/s41556-018-0184-2. https://pubmed.ncbi.nlm.nih.gov/30089842/\nEvidence access: Primary full text\nAspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours. · 2018 · https://pubmed.ncbi.nlm.nih.gov/29941933/ · DOI 10.1038/s41556-018-0118-z","model_system":"Human tumor metabolite and marker analysis.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"67970dcb-34e0-5b0a-8c86-d8c3cc183444","stable_key":"import-e37461ea-ea5d-5e2c-8091-138305f6dd70","title":"L-Aspartate: redox transfer, nitrogen partitioning and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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