{"id":"8acc6835-3963-544b-9fe8-47a194ec7ccd","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-duodenal-ph","predicate":"increases_tested","statement":"Luminal L-glutamate increased epithelial pH in rat duodenum.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2bb3b0fc-148e-5081-a0cc-43188afd3e36","mechanism_event_label":"A luminal amino acid changed cellular acid-base handling.","subject":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"object":{"id":"8427ecb2-ca50-5973-907e-be8f910ed68d","slug":"rat-duodenal-epithelial-ph","display_name":"Rat duodenal epithelial intracellular pH","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2bb3b0fc-148e-5081-a0cc-43188afd3e36","stable_key":"561b2b40-5b59-548f-a749-f357f7e2304c:monosodium-glutamate-duodenal-ph-event","event_type":"observed_relationship","label":"A luminal amino acid changed cellular acid-base handling.","description":"Luminal L-glutamate increased epithelial pH in rat duodenum.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8427ecb2-ca50-5973-907e-be8f910ed68d","slug":"rat-duodenal-epithelial-ph","display_name":"Rat duodenal epithelial intracellular pH","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2952387b-d69b-5530-a976-a875ad008226","slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Anesthetized-rat perfusion, 0.1–10 mM.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Local preparation; not blood alkalinization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Monosodium Glutamate (MSG) collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"monosodium-glutamate","display_name":"Monosodium L-glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A luminal amino acid changed cellular acid-base handling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19643955/ · DOI 10.1152/ajpgi.90605.2008","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a1f432e1-4d0f-59de-ad65-0e438a2009ce","evidence_kind":"source_excerpt","locator":"Lines 178-184","start_line":178,"end_line":184,"excerpt":"## monosodium-glutamate-duodenal-ph\nA luminal amino acid changed cellular acid-base handling.\nLuminal L-glutamate increased epithelial pH in rat duodenum.\nModel: Anesthetized-rat perfusion, 0.1–10 mM.\nLimitations: Local preparation; not blood alkalinization.\nEvidence access: Primary abstract\nLuminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19643955/ · DOI 10.1152/ajpgi.90605.2008","model_system":"Anesthetized-rat perfusion, 0.1–10 mM.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"90a81fe5-8622-52f6-b4db-04899206c2b0","stable_key":"import-561b2b40-5b59-548f-a749-f357f7e2304c","title":"Monosodium Glutamate (MSG): taste, gut sensing, exposure and cross-nutrient mechanisms (2026-09-20)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"53052c19ee82d400eff7d82ffa3cff74747c7f91a8d173efa3f46eba6bd87cce","revision_id":"fdb64139-32f4-537e-bb0f-f242f2779da8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}