{"id":"8acb8bbd-bed7-5d50-8910-9c43b424bbb5","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-parkinson-null","predicate":"did_not_slow","statement":"Neither CoQ dose slowed UPDRS worsening versus placebo; the trial stopped for futility.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b0d57498-b761-5f8d-a3bc-d6f1865773e2","mechanism_event_label":"A plausible mitochondrial mechanism did not translate into slower Parkinson progression in this trial.","subject":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"object":{"id":"4159dc98-5f4f-547e-8dc0-35c7b3f79d69","slug":"parkinson-updrs-progression","display_name":"Parkinson disease UPDRS progression","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b0d57498-b761-5f8d-a3bc-d6f1865773e2","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-parkinson-null-event","event_type":"observed_intervention","label":"A plausible mitochondrial mechanism did not translate into slower Parkinson progression in this trial.","description":"Neither CoQ dose slowed UPDRS worsening versus placebo; the trial stopped for futility.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e67a0437-6900-5f53-8b03-c0a7ad6d92b6","slug":"vitamin-e","display_name":"Vitamin E","entity_type_key":"chemical_species"},"role":"background_intervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4159dc98-5f4f-547e-8dc0-35c7b3f79d69","slug":"parkinson-updrs-progression","display_name":"Parkinson disease UPDRS progression","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/24664227.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b1f301e82d4650432dab586db0be51f96e131f3c6084af9aebde932e8072676b\", \"start_char\": 0, \"end_char\": 3023, \"text_sha256\": \"b1f301e82d4650432dab586db0be51f96e131f3c6084af9aebde932e8072676b\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind phase III trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"CoQ10 1200 or 2400 mg/day; all groups received 1200 IU/day vitamin E","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Vitamin E was a common background intervention; this comparison cannot identify its independent effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"600 early-Parkinson patients","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A plausible mitochondrial mechanism did not translate into slower Parkinson progression in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p24664227] A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. (2014). https://pubmed.ncbi.nlm.nih.gov/24664227/ DOI: 10.1001/jamaneurol.2014.131","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"UPDRS progression","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"35c07207-3cfc-5832-8195-ae6501836967","evidence_kind":"source_excerpt","locator":"Lines 1217-1228","start_line":1217,"end_line":1228,"excerpt":"### coq10-parkinson-null\nNeither CoQ dose slowed UPDRS worsening versus placebo; the trial stopped for futility.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A plausible mitochondrial mechanism did not translate into slower Parkinson progression in this trial.\norganism: 600 early-Parkinson patients\ntissue_or_cell_type: UPDRS progression\nexperimental_model: Randomized double-blind phase III trial\nlimitations: Vitamin E was a common background intervention; this comparison cannot identify its independent effect.\nexposure: CoQ10 1200 or 2400 mg/day; all groups received 1200 IU/day vitamin E\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/24664227.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b1f301e82d4650432dab586db0be51f96e131f3c6084af9aebde932e8072676b\", \"start_char\": 0, \"end_char\": 3023, \"text_sha256\": \"b1f301e82d4650432dab586db0be51f96e131f3c6084af9aebde932e8072676b\"}\n[coq10-p24664227] A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. 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