{"id":"8a8885e0-9a44-591f-871f-97e0be0e68e9","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-ileal-sodium","predicate":"increases","statement":"Pectin increased sodium output in ileal effluent.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"846bd58f-d1f1-5863-a597-0b305fc301ab","mechanism_event_label":"More sodium left through the ileostomy; this is not proof of low blood sodium.","subject":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"object":{"id":"32b3b1a0-7c77-532f-b1d5-eb1ef608bb03","slug":"human-ileal-sodium-loss","display_name":"Human ileal sodium output","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"846bd58f-d1f1-5863-a597-0b305fc301ab","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-ileal-sodium-event","event_type":"observed_intervention","label":"More sodium left through the ileostomy; this is not proof of low blood sodium.","description":"Pectin increased sodium output in ileal effluent.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e4aaa90-5b94-5d69-ba79-d760da4e0268","slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"},"role":"measured_substance","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"32b3b1a0-7c77-532f-b1d5-eb1ef608bb03","slug":"human-ileal-sodium-loss","display_name":"Human ileal sodium output","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/6307932.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1\", \"start_char\": 0, \"end_char\": 1593, \"text_sha256\": \"fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Within-person ileostomy balance study; six participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 g/day citrus pectin on days 5-7 of a 10-day low-fiber feeding protocol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ileal apparent absorption and output are not whole-body status or clinical deficiency; the colon was bypassed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"More sodium left through the ileostomy; this is not proof of low blood sodium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p6307932] The effect of citrus pectin on the absorption of nutrients in the small intestine. (1983). https://pubmed.ncbi.nlm.nih.gov/6307932/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Small intestine; ileal effluent","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9939f6bd-2b55-5465-a939-2a6e7ea44357","evidence_kind":"source_excerpt","locator":"Lines 555-566","start_line":555,"end_line":566,"excerpt":"### pectin-ileal-sodium\nPectin increased sodium output in ileal effluent.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: More sodium left through the ileostomy; this is not proof of low blood sodium.\norganism: Homo sapiens\ntissue_or_cell_type: Small intestine; ileal effluent\nexperimental_model: Within-person ileostomy balance study; six participants\nlimitations: Ileal apparent absorption and output are not whole-body status or clinical deficiency; the colon was bypassed.\nexposure: 15 g/day citrus pectin on days 5-7 of a 10-day low-fiber feeding protocol\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/6307932.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1\", \"start_char\": 0, \"end_char\": 1593, \"text_sha256\": \"fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1\"}\n[pectin-p6307932] The effect of citrus pectin on the absorption of nutrients in the small intestine. (1983). https://pubmed.ncbi.nlm.nih.gov/6307932/","model_system":"Within-person ileostomy balance study; six participants","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [pectin-p6307932] The effect of citrus pectin on the absorption of nutrients in the small intestine. (1983). https://pubmed.ncbi.nlm.nih.gov/6307932/","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"13c3aae7-702f-5bc9-9fca-a57d141882ce","stable_key":"import-d17caac5-7018-5ca8-9e96-95afeb384bc4","title":"Pectin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff07001bc37d008a1e23fbba37146d0b0d33cc8c0bf42a75f1e1a7ef0aaeb489","revision_id":"76f1a2c5-02d0-511b-bde5-33079d7af6a0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}