{"id":"8a3609c6-597e-53a6-aa2b-ec8d654ab50c","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-clamp-insulin-sensitivity","predicate":"increases","statement":"The exploratory clamp trial found a 27% greater change in glucose-disposal clearance versus placebo after pooling ALA groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"41cb93f3-700a-5bbc-a45e-da95932fa374","mechanism_event_label":"Insulin sensitivity improved in this small short-term experiment.","subject":{"id":"ab091982-3acb-5a87-80fb-85dfe292c1e0","slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"},"object":{"id":"81a36c35-7133-5b73-9219-81567127bbb2","slug":"insulin-stimulated-glucose-disposal","display_name":"Insulin-stimulated glucose disposal","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"41cb93f3-700a-5bbc-a45e-da95932fa374","stable_key":"5d8e27d8-6a74-5560-827f-3f90908bbc34:ala-clamp-insulin-sensitivity-event","event_type":"observed_intervention","label":"Insulin sensitivity improved in this small short-term experiment.","description":"The exploratory clamp trial found a 27% greater change in glucose-disposal clearance versus placebo after pooling ALA groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ab091982-3acb-5a87-80fb-85dfe292c1e0","slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"81a36c35-7133-5b73-9219-81567127bbb2","slug":"insulin-stimulated-glucose-disposal","display_name":"Insulin-stimulated glucose disposal","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/ala-research/10468203.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"06f09aa0ad208b561612e62d5ce388b90205f8e767f1cf96545162ec2bf24a9a\", \"start_char\": 0, \"end_char\": 2007, \"text_sha256\": \"06f09aa0ad208b561612e62d5ce388b90205f8e767f1cf96545162ec2bf24a9a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Exploratory randomized placebo-controlled glucose-clamp pilot","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"600, 1200 or 1800 mg/day oral ALA for four weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Active doses were pooled after no dose effect was detected; exploratory design and surrogate outcome, not long-term diabetes complications.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lipoic-acid","display_name":"Lipoic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Insulin sensitivity improved in this small short-term experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ala-p10468203] Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. (1999). https://pubmed.ncbi.nlm.nih.gov/10468203/ DOI: 10.1016/s0891-5849(99)00089-1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"74 participants with type 2 diabetes","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a8b7649d-eeb7-536c-9913-337f5d0c3416","evidence_kind":"source_excerpt","locator":"Lines 1196-1207","start_line":1196,"end_line":1207,"excerpt":"### ala-clamp-insulin-sensitivity\nThe exploratory clamp trial found a 27% greater change in glucose-disposal clearance versus placebo after pooling ALA groups.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Insulin sensitivity improved in this small short-term experiment.\norganism: Human\ntissue_or_cell_type: 74 participants with type 2 diabetes\nexperimental_model: Exploratory randomized placebo-controlled glucose-clamp pilot\nlimitations: Active doses were pooled after no dose effect was detected; exploratory design and surrogate outcome, not long-term diabetes complications.\nexposure: 600, 1200 or 1800 mg/day oral ALA for four weeks\nevidence_span: {\"source_cache\": \"artifacts/ala-research/10468203.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"06f09aa0ad208b561612e62d5ce388b90205f8e767f1cf96545162ec2bf24a9a\", \"start_char\": 0, \"end_char\": 2007, \"text_sha256\": \"06f09aa0ad208b561612e62d5ce388b90205f8e767f1cf96545162ec2bf24a9a\"}\n[ala-p10468203] Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. (1999). https://pubmed.ncbi.nlm.nih.gov/10468203/ DOI: 10.1016/s0891-5849(99)00089-1","model_system":"Exploratory randomized placebo-controlled glucose-clamp pilot","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ala-p10468203] Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. 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