{"id":"89ffc961-304c-5ce2-b50a-55a16b67459e","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-sweetness-glp1-null","predicate":"sweetness_replacement_does_not_restore","statement":"Matching sweetness with nonnutritive sweeteners did not restore the GLP-1 response lost when meal sucrose was reduced.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ebd13be3-b12c-5368-82d3-d0bc7528455e","mechanism_event_label":"Matching sweetness with nonnutritive sweeteners did not restore the GLP-1 response lost when meal sucrose was reduced.","subject":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"object":{"id":"9086d887-f5ea-5dfb-a68f-adb2c2bda3c7","slug":"plasma-glp1-response","display_name":"Plasma GLP-1 response in the specified meal or glucose challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ebd13be3-b12c-5368-82d3-d0bc7528455e","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-sweetness-glp1-null-event","event_type":"observed_relationship","label":"Matching sweetness with nonnutritive sweeteners did not restore the GLP-1 response lost when meal sucrose was reduced.","description":"Matching sweetness with nonnutritive sweeteners did not restore the GLP-1 response lost when meal sucrose was reduced.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9086d887-f5ea-5dfb-a68f-adb2c2bda3c7","slug":"plasma-glp1-response","display_name":"Plasma GLP-1 response in the specified meal or glucose challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4853afc6-9eaa-547f-91d7-c4dd90082351","slug":"glp-1","display_name":"Glucagon-like peptide 1 / GLP-1","entity_type_key":"peptide"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"15bd1664-9d4b-514f-ab83-87274a67673f","slug":"aspartame","display_name":"Aspartame","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"50 versus 5 g sucrose; 5 g plus mixed sucralose/acesulfame/aspartame/erythritol to match sweetness","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"15-minute comparison; sampling to 60 minutes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata inspected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy Japanese men in low-sucrose meal substudy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Sucrose dose versus matched perceived sweetness","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Methods say n=6 for sweetener substudy, results report n=7; discrepancy preserved. Lower sucrose also lowers calories; this is not a calorie-matched isolated receptor experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy Japanese men in low-sucrose meal substudy","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Matching sweetness with nonnutritive sweeteners did not restore the GLP-1 response lost when meal sucrose was reduced.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar vs non-nutritive sweetener. (2012). https://pubmed.ncbi.nlm.nih.gov/24843559/ DOI: 10.1111/j.2040-1124.2011.00163.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral mixed meal","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma active GLP-1 after mixed meal","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"396016ce-5829-58dc-a90e-6dba7f95a7b4","evidence_kind":"source_excerpt","locator":"Lines 259-269","start_line":259,"end_line":269,"excerpt":"## sucrose-sweetness-glp1-null\nMatching sweetness with nonnutritive sweeteners did not restore the GLP-1 response lost when meal sucrose was reduced.\nModel/species: Healthy Japanese men in low-sucrose meal substudy\nTissue: Plasma active GLP-1 after mixed meal\nExposure: 50 versus 5 g sucrose; 5 g plus mixed sucralose/acesulfame/aspartame/erythritol to match sweetness\nRoute: Oral mixed meal\nDuration: 15-minute comparison; sampling to 60 minutes\nExposure scope: Sucrose dose versus matched perceived sweetness\nLimits: Methods say n=6 for sweetener substudy, results report n=7; discrepancy preserved. Lower sucrose also lowers calories; this is not a calorie-matched isolated receptor experiment.\nReference: Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar vs non-nutritive sweetener. (2012). https://pubmed.ncbi.nlm.nih.gov/24843559/ DOI: 10.1111/j.2040-1124.2011.00163.x\nAccess: Primary full-text methods/results and metadata inspected.","model_system":"Healthy Japanese men in low-sucrose meal substudy","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text.","file_path":"","sha256":"5e68ccbade7a80fc03778495756f0eeeeba5038cd10d5bef8e33cb1e93e4b044","revision_id":"6edb8ffc-11c5-5cd9-852c-85adb71165a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}