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Substrate overlap describes a shared route, not a predicted clinical interaction.\nexposure: Oppositely directed proton gradient; Michaelis-Menten constants for ten substrates\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/17509534.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d2660dd67050133c958e8aa13cf2ac6b574bd56fcefa116d3a73c3db4a7cea44\", \"start_char\": 0, \"end_char\": 1841, \"text_sha256\": \"d2660dd67050133c958e8aa13cf2ac6b574bd56fcefa116d3a73c3db4a7cea44\"}\n[metformin-p17509534] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. 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