{"id":"899a7481-14b3-553a-a4a2-76ec0fb489f1","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-iron-vitc-lowcu-anemia","predicate":"with_high_iron_worsens","statement":"High iron together with dietary ascorbate aggravated anemia in copper-deficient rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"946c40e4-ccfa-516f-bfb5-ed051d143c37","mechanism_event_label":"A nutrient combination worsened the deficit in this animal setting.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"3ca86e56-991e-532b-b8be-c1445d560949","slug":"rat-copper-deficiency-anemia","display_name":"Anemia in copper-deficient rats","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"946c40e4-ccfa-516f-bfb5-ed051d143c37","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-iron-vitc-lowcu-anemia-event","event_type":"biochemical_relationship","label":"A nutrient combination worsened the deficit in this animal setting.","description":"High iron together with dietary ascorbate aggravated anemia in copper-deficient rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"co-exposure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"deficient nutrient","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3ca86e56-991e-532b-b8be-c1445d560949","slug":"rat-copper-deficiency-anemia","display_name":"Anemia in copper-deficient rats","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/3337044.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2302118b1dad186fdee87512abf58f47a36d430e329057c87b24e57e52e331cc\", \"start_char\": 0, \"end_char\": 882, \"text_sha256\": \"2302118b1dad186fdee87512abf58f47a36d430e329057c87b24e57e52e331cc\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Factorial dietary copper, iron and ascorbate feeding experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Copper 0.42 versus 5.74 micrograms/g diet; iron 38 versus 191 micrograms/g; ascorbate 0 versus 1%, for 20 days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal feed concentrations cannot be converted into a human supplement rule. 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(1988). https://pubmed.ncbi.nlm.nih.gov/3337044/ DOI: 10.1093/ajcn/47.1.96","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal uptake, blood and tissues","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e4e189eb-663d-5a65-a142-9a9d97bc73de","evidence_kind":"source_excerpt","locator":"Lines 1157-1168","start_line":1157,"end_line":1168,"excerpt":"### copper-iron-vitc-lowcu-anemia\nHigh iron together with dietary ascorbate aggravated anemia in copper-deficient rats.\nCondition category: nutrient_deficiency\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A nutrient combination worsened the deficit in this animal setting.\norganism: Rat\ntissue_or_cell_type: Intestinal uptake, blood and tissues\nexperimental_model: Factorial dietary copper, iron and ascorbate feeding experiment\nlimitations: Animal feed concentrations cannot be converted into a human supplement rule. Baseline copper status modified effects.\nexposure: Copper 0.42 versus 5.74 micrograms/g diet; iron 38 versus 191 micrograms/g; ascorbate 0 versus 1%, for 20 days\nevidence_span: {\"source_cache\": \"artifacts/copper-research/3337044.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2302118b1dad186fdee87512abf58f47a36d430e329057c87b24e57e52e331cc\", \"start_char\": 0, \"end_char\": 882, \"text_sha256\": \"2302118b1dad186fdee87512abf58f47a36d430e329057c87b24e57e52e331cc\"}\n[copper-p3337044] Adverse effects of high dietary iron and ascorbic acid on copper status in copper-deficient and copper-adequate rats. (1988). https://pubmed.ncbi.nlm.nih.gov/3337044/ DOI: 10.1093/ajcn/47.1.96","model_system":"Factorial dietary copper, iron and ascorbate feeding experiment","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p3337044] Adverse effects of high dietary iron and ascorbic acid on copper status in copper-deficient and copper-adequate rats. (1988). https://pubmed.ncbi.nlm.nih.gov/3337044/ DOI: 10.1093/ajcn/47.1.96","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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