{"id":"894a539a-e67d-5872-af7d-fea7b79bf6d8","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-glycine-receptor-alpha2","predicate":"activates","statement":"Applied taurine also activated human alpha2 homomeric glycine receptors, with efficacy varying from weak to full agonism across tested conditions.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2d01aabd-ff03-5fe5-92c7-1672dea3e820","mechanism_event_label":"The receptor subtype and cell setting change the strength of taurine signaling.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"e031a624-9e12-5807-9bf5-96aa484dabc0","slug":"human-glra2-homomer","display_name":"Human alpha2 homomeric glycine receptor","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"2d01aabd-ff03-5fe5-92c7-1672dea3e820","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-glycine-receptor-alpha2-event","event_type":"observed_relationship","label":"The receptor subtype and cell setting change the strength of taurine signaling.","description":"Applied taurine also activated human alpha2 homomeric glycine receptors, with efficacy varying from weak to full agonism across tested conditions.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e031a624-9e12-5807-9bf5-96aa484dabc0","slug":"human-glra2-homomer","display_name":"Human alpha2 homomeric glycine receptor","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human alpha2 receptor electrophysiology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Avoid labeling taurine a universally weak or full agonist.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The receptor subtype and cell setting change the strength of taurine signaling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11559772/ · DOI 10.1111/j.1469-7793.2001.t01-1-00741.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0163a3b8-6d25-55e7-abed-3ad3ea979547","evidence_kind":"source_excerpt","locator":"Lines 425-431","start_line":425,"end_line":431,"excerpt":"## taurine-glycine-receptor-alpha2\nThe receptor subtype and cell setting change the strength of taurine signaling.\nApplied taurine also activated human alpha2 homomeric glycine receptors, with efficacy varying from weak to full agonism across tested conditions.\nModel: Recombinant human alpha2 receptor electrophysiology.\nLimitations: Avoid labeling taurine a universally weak or full agonist.\nEvidence access: Primary abstract\nActivation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11559772/ · DOI 10.1111/j.1469-7793.2001.t01-1-00741.x","model_system":"Recombinant human alpha2 receptor electrophysiology.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}