{"id":"88fb7156-9d26-59a7-953f-a49cf829b9e8","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:the-same-trial-lowers-von-willebrand-factor-in-women","predicate":"reduces","statement":"A decrease in von Willebrand factor was seen in the female participants taking nattokinase, at p < 0.1.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8f784e93-6ffe-5191-8841-766bd42b499e","mechanism_event_label":"A decrease in von Willebrand factor was seen in the female participants taking nattokinase, at p < 0.1.","subject":{"id":"9910223c-2a27-5d75-8003-91d72e71be9a","slug":"nsk-sd","display_name":"NSK-SD fermented soybean extract","entity_type_key":"chemical_species"},"object":{"id":"d1c324a6-f2c0-550e-ad72-f3fa04a924f8","slug":"vwf","display_name":"Human von Willebrand factor / VWF","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"8f784e93-6ffe-5191-8841-766bd42b499e","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:the-same-trial-lowers-von-willebrand-factor-in-women-event","event_type":"observed_intervention","label":"A decrease in von Willebrand factor was seen in the female participants taking nattokinase, at p < 0.1.","description":"Plasma","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9910223c-2a27-5d75-8003-91d72e71be9a","slug":"nsk-sd","display_name":"NSK-SD fermented soybean extract","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"d1c324a6-f2c0-550e-ad72-f3fa04a924f8","slug":"vwf","display_name":"Human von Willebrand factor / VWF","entity_type_key":"protein"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human (74 completers with elevated blood pressure)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"NSK-SD, 100 mg per day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Exploratory, sex-restricted and above the conventional significance threshold. It is the only human measurement in this chapter that touches the von Willebrand factor mechanism, which makes it worth recording and makes over-reading it easy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Human (74 completers with elevated blood pressure)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A decrease in von Willebrand factor was seen in the female participants taking nattokinase, at p < 0.1.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. (2016) https://pubmed.ncbi.nlm.nih.gov/27785095/ DOI: 10.2147/IBPC.S99553","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vivo, oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cd8cfd05-02b7-5f1d-b227-7e3204941609","evidence_kind":"source_excerpt","locator":"Lines 1027-1027","start_line":1027,"end_line":1027,"excerpt":"A decrease in von Willebrand factor was seen in the female participants taking nattokinase, at p < 0.1.","model_system":"Human (74 completers with elevated blood pressure)","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"41cb127c-1c23-53aa-b7d0-5ec7f6fa3c99","stable_key":"import-33bef151-bdc7-5892-aff6-0345ab149739","title":"Nattokinase: what the purified enzyme cleaves, what survives being eaten, and the gap between the two (2026-09-23)","document_type":"imported_text","citation_label":"Original AI-assisted curation built from a supplied entity-first document of 105 entities and 129 claims. Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. Not publisher full text.","file_path":"","sha256":"34fc46e0e849d06bfa13cb099a79b50679dd6fd0de8a5a0575326afdde3259c1","revision_id":"efd063e6-e982-5f6e-a4b8-6f2ffe4185ce","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}