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(2014). https://pubmed.ncbi.nlm.nih.gov/25506250/ DOI: 10.2147/cpaa.s71574","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3a71ce4c-b47b-5c4d-ad04-9fd37ce4f982","evidence_kind":"source_excerpt","locator":"Lines 637-648","start_line":637,"end_line":648,"excerpt":"### ala-oral-formulation-exposure\nCompared with solution, the tested tablets produced R-lipoic-acid peak concentrations of 36–43% and exposure areas of 64–79%.\nCondition category: normal\nnutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Different formulations delivered different amounts into blood.\norganism: Human\ntissue_or_cell_type: Plasma\nexperimental_model: Randomized four-way crossover pharmacokinetic study in 24 healthy volunteers\nlimitations: Exposure differences are formulation specific; plasma pharmacokinetics does not establish clinical efficacy or mitochondrial attachment.\nexposure: Single 600-mg racemic oral formulations: solution and tablets\nevidence_span: {\"source_cache\": \"artifacts/ala-research/25506250.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"539058a215e046b23d352d40f72f6e4fd9259b6e746770584d8852d650990973\", \"start_char\": 0, \"end_char\": 2050, \"text_sha256\": \"539058a215e046b23d352d40f72f6e4fd9259b6e746770584d8852d650990973\"}\n[ala-p25506250] Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms. 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