{"id":"88c2de1f-66c9-5d5d-bdff-5ca93b5ec44d","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-thc-metabolites","predicate":"is_converted_to","statement":"Plasma cannabinoid pharmacokinetics following controlled oral THC and oromucosal cannabis extract administration resolved the time courses of THC and its metabolites.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"be9c0ef9-7aa6-5dd2-977a-3e65e9bdd113","mechanism_event_label":"The drug is measured alongside the two metabolites it becomes.","subject":{"id":"5a9e5b75-e6aa-5684-ad62-8a8d60148c84","slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"},"object":{"id":"163de57d-883d-5932-8c4b-924232a5ed2e","slug":"11-oh-thc","display_name":"11-hydroxy-delta-9-tetrahydrocannabinol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"be9c0ef9-7aa6-5dd2-977a-3e65e9bdd113","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-thc-metabolites-event","event_type":"observed_intervention","label":"The drug is measured alongside the two metabolites it becomes.","description":"Plasma cannabinoid pharmacokinetics following controlled oral THC and oromucosal cannabis extract administration resolved the time courses of THC and its metabolites.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4049a6dc-185f-50ca-9a62-1d97a537ca85","slug":"thc-cooh","display_name":"11-nor-9-carboxy-delta-9-tetrahydrocannabinol","entity_type_key":"small_molecule"},"role":"further_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ec29634e-5593-5bc5-aa66-ca5987efefc2","slug":"plasma-thc-concentration","display_name":"Plasma THC concentration","entity_type_key":"cellular_process"},"role":"measured_process","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5a9e5b75-e6aa-5684-ad62-8a8d60148c84","slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"163de57d-883d-5932-8c4b-924232a5ed2e","slug":"11-oh-thc","display_name":"11-hydroxy-delta-9-tetrahydrocannabinol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/thc-research/21078841.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0ae96dadadcd8c1ee096e38d9a531fc9182b5670b97837d6d1ddad9cd611e2f9\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"0ae96dadadcd8c1ee096e38d9a531fc9182b5670b97837d6d1ddad9cd611e2f9\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled oral THC and oromucosal cannabis extract with serial plasma sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Controlled oral THC and oromucosal extract dosing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A controlled human pharmacokinetic study with the metabolites measured. Oral and oromucosal routes only; it does not describe smoked exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The drug is measured alongside the two metabolites it becomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p21078841] Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration. (2011). https://pubmed.ncbi.nlm.nih.gov/21078841/ DOI: 10.1373/clinchem.2010.152439","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"69146787-eb8e-576c-af70-30beff167065","evidence_kind":"source_excerpt","locator":"Lines 517-528","start_line":517,"end_line":528,"excerpt":"### thc-thc-metabolites\nPlasma cannabinoid pharmacokinetics following controlled oral THC and oromucosal cannabis extract administration resolved the time courses of THC and its metabolites.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: The drug is measured alongside the two metabolites it becomes.\norganism: Human\ntissue_or_cell_type: Plasma\nexperimental_model: Controlled oral THC and oromucosal cannabis extract with serial plasma sampling\nlimitations: A controlled human pharmacokinetic study with the metabolites measured. Oral and oromucosal routes only; it does not describe smoked exposure.\nexposure: Controlled oral THC and oromucosal extract dosing\nevidence_span: {\"source_cache\": \"artifacts/thc-research/21078841.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0ae96dadadcd8c1ee096e38d9a531fc9182b5670b97837d6d1ddad9cd611e2f9\", \"start_char\": 0, \"end_char\": 1727, \"text_sha256\": \"0ae96dadadcd8c1ee096e38d9a531fc9182b5670b97837d6d1ddad9cd611e2f9\"}\n[thc-p21078841] Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration. (2011). https://pubmed.ncbi.nlm.nih.gov/21078841/ DOI: 10.1373/clinchem.2010.152439","model_system":"Controlled oral THC and oromucosal cannabis extract with serial plasma sampling","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [thc-p21078841] Plasma cannabinoid pharmacokinetics following controlled oral delta9-tetrahydrocannabinol and oromucosal cannabis extract administration. (2011). https://pubmed.ncbi.nlm.nih.gov/21078841/ DOI: 10.1373/clinchem.2010.152439","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b4367320-9724-507a-bead-6932fa0a78cb","stable_key":"import-05a3cf47-e660-5ab3-8c32-5eba9847cf0a","title":"THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"60abc81737d18b7a50b01ca487e38291774ee15d9777651aa2d3eac8670ac3b2","revision_id":"2cba3552-af89-580d-b20a-8cfb1b14f9e7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}