{"id":"88c10ba5-77e1-594e-8d4b-4dad3f372a7c","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-ckd-kcl-bicarbonate-response","predicate":"supplementation_reduces","statement":"The same KCl run-in modestly lowered mean bicarbonate from 24.5 to 23.7 mmol/L and increased chloride; urinary ammonium did not increase.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"21bf1609-02aa-5e99-81d0-2a921b001e66","mechanism_event_label":"The chloride salt affected acid-base measurements as well as potassium.","subject":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"object":{"id":"d838c3fe-9d18-5c31-a014-ffc943cb0f58","slug":"plasma-bicarbonate-concentration","display_name":"Plasma bicarbonate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"21bf1609-02aa-5e99-81d0-2a921b001e66","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-ckd-kcl-bicarbonate-response-event","event_type":"observed_intervention","label":"The chloride salt affected acid-base measurements as well as potassium.","description":"The same KCl run-in modestly lowered mean bicarbonate from 24.5 to 23.7 mmol/L and increased chloride; 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urinary ammonium did not increase.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The chloride salt affected acid-base measurements as well as potassium.\norganism: Homo sapiens\ntissue_or_cell_type: Plasma and urine\nexperimental_model: Same two-week CKD cohort.\nlimitations: No randomized comparator; no significant blood-pressure or eGFR change.\ncross_nutrient: Potassium salt/chloride -> acid-base balance.\n[k-gritter2022] Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD (2022). https://pubmed.ncbi.nlm.nih.gov/35609996/ DOI: 10.1681/asn.2022020147","model_system":"Same two-week CKD cohort.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-gritter2022] Effects of Short-Term Potassium Chloride Supplementation in Patients with CKD (2022). https://pubmed.ncbi.nlm.nih.gov/35609996/ DOI: 10.1681/asn.2022020147","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}