{"id":"88ae8af6-728c-5618-86ef-f16958d8a0d2","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-microbial-hppa","predicate":"is_microbially_degraded_toward","statement":"One donor's fecal water produced 4-HPPA from naringenin, while downstream 4-HPPA degradation differed among 22 donors.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4bc5614d-fc30-5ca6-9d93-9f620355326f","mechanism_event_label":"One donor's fecal water produced 4-HPPA from naringenin, while downstream 4-HPPA degradation differed among 22 donors.","subject":{"id":"2a9350f6-01cc-5bea-8213-cd3ebb1b05cf","slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"},"object":{"id":"f740c865-fdc1-561f-a59b-f1b6dddbbc0a","slug":"4-hydroxyphenylpropionic-acid","display_name":"3-(4-Hydroxyphenyl)propionic acid / 4-HPPA","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"4bc5614d-fc30-5ca6-9d93-9f620355326f","stable_key":"d2e91bc7-8177-5ad3-ad9b-5d65813ce082:naringenin-microbial-hppa-event","event_type":"observed_relationship","label":"One donor's fecal water produced 4-HPPA from naringenin, while downstream 4-HPPA degradation differed among 22 donors.","description":"One donor's fecal water produced 4-HPPA from naringenin, while downstream 4-HPPA degradation differed among 22 donors.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2a9350f6-01cc-5bea-8213-cd3ebb1b05cf","slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f740c865-fdc1-561f-a59b-f1b6dddbbc0a","slug":"4-hydroxyphenylpropionic-acid","display_name":"3-(4-Hydroxyphenyl)propionic acid / 4-HPPA","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Naringenin or 4-HPPA incubation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Incubation study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human fecal incubations from six and then 22 donors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Absence of measured 4-HPPA in five donors may reflect faster downstream degradation rather than absent formation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Naringenin chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"naringenin","display_name":"Naringenin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human fecal incubations from six and then 22 donors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One donor's fecal water produced 4-HPPA from naringenin, while downstream 4-HPPA degradation differed among 22 donors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human intestinal microbial metabolism of naringin. (2015). https://pubmed.ncbi.nlm.nih.gov/24935725/ DOI: 10.1007/s13318-014-0193-x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Microbial naringenin and 4-HPPA metabolism","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"030bc2a8-82e9-57f2-a0b1-360738634629","evidence_kind":"source_excerpt","locator":"Lines 33-42","start_line":33,"end_line":42,"excerpt":"## naringenin-microbial-hppa\nOne donor's fecal water produced 4-HPPA from naringenin, while downstream 4-HPPA degradation differed among 22 donors.\nModel/species: Human fecal incubations from six and then 22 donors\nTissue/system: Microbial naringenin and 4-HPPA metabolism\nExposure: Naringenin or 4-HPPA incubation\nRoute: Ex vivo\nDuration: Incubation study\nLimits: Absence of measured 4-HPPA in five donors may reflect faster downstream degradation rather than absent formation.\nPrimary reference: Human intestinal microbial metabolism of naringin. (2015). https://pubmed.ncbi.nlm.nih.gov/24935725/ DOI: 10.1007/s13318-014-0193-x\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Human fecal incubations from six and then 22 donors","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2804932d-46eb-5c43-8a45-0505e6b1ee05","stable_key":"import-d2e91bc7-8177-5ad3-ad9b-5d65813ce082","title":"Naringenin: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"e74776bf312a9ab53a4510c483e36e3093829e8c38725b9ae061e59e86f1145a","revision_id":"b96b5487-2b33-56ff-8955-9e8c0833533b","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}