{"id":"88abf51d-b52a-5c64-a0f8-85b53c84ab54","stable_key":"d8050016-13c9-5391-9d61-63de73590053:zeaxanthin-unsaturated-quenching","predicate":"reduces","statement":"Zeaxanthin decreased the detected singlet-oxygen concentration in unsaturated-lipid liposomes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5c0d8adc-9aec-5dcd-87bd-0ce9864056a9","mechanism_event_label":"Protection depended on the surrounding membrane.","subject":{"id":"0a60c685-7502-5ece-9da2-2c1a2e3bcdf1","slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"},"object":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"5c0d8adc-9aec-5dcd-87bd-0ce9864056a9","stable_key":"d8050016-13c9-5391-9d61-63de73590053:zeaxanthin-unsaturated-quenching-event","event_type":"biochemical_relationship","label":"Protection depended on the surrounding membrane.","description":"Zeaxanthin decreased the detected singlet-oxygen concentration in unsaturated-lipid liposomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0a60c685-7502-5ece-9da2-2c1a2e3bcdf1","slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac4a9e3e-1454-5802-82a3-3b3b18afc417","slug":"singlet-oxygen","display_name":"Singlet molecular oxygen","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zeaxanthin-research/30689980.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"94c10c1ffd51016a2038f725e1e38457c47b5c929bd89f7222d8bc84a7f76743\", \"start_char\": 0, \"end_char\": 1545, \"text_sha256\": \"94c10c1ffd51016a2038f725e1e38457c47b5c929bd89f7222d8bc84a7f76743\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Photosensitized liposome experiment","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Carotenoids at 0.15 mol%; toluidine-blue photosensitization","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Measured effects depended on membrane composition; do not generalize the saturated-membrane null to all antioxidant chemistry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zeaxanthin","display_name":"Dietary (3R,3-prime-R)-zeaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Cell-free lipid systems","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Protection depended on the surrounding membrane.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zeaxanthin-p30689980] The effect of carotenoids on the concentration of singlet oxygen in lipid membranes. (2019). https://pubmed.ncbi.nlm.nih.gov/30689980/ DOI: 10.1016/j.bbamem.2019.01.012","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Saturated versus unsaturated lipid bilayers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"95091f23-a5c6-589c-8b2b-7978a0d9556c","evidence_kind":"source_excerpt","locator":"Lines 327-338","start_line":327,"end_line":338,"excerpt":"### zeaxanthin-unsaturated-quenching\nZeaxanthin decreased the detected singlet-oxygen concentration in unsaturated-lipid liposomes.\nCondition category: normal\nnutrient_topic: Zeaxanthin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Protection depended on the surrounding membrane.\norganism: Cell-free lipid systems\ntissue_or_cell_type: Saturated versus unsaturated lipid bilayers\nexperimental_model: Photosensitized liposome experiment\nlimitations: Measured effects depended on membrane composition; do not generalize the saturated-membrane null to all antioxidant chemistry.\nexposure: Carotenoids at 0.15 mol%; toluidine-blue photosensitization\nevidence_span: {\"source_cache\": \"artifacts/zeaxanthin-research/30689980.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"94c10c1ffd51016a2038f725e1e38457c47b5c929bd89f7222d8bc84a7f76743\", \"start_char\": 0, \"end_char\": 1545, \"text_sha256\": \"94c10c1ffd51016a2038f725e1e38457c47b5c929bd89f7222d8bc84a7f76743\"}\n[zeaxanthin-p30689980] The effect of carotenoids on the concentration of singlet oxygen in lipid membranes. 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