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Missing follow-up, baseline metabolic status and preparation constrain generalization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ceylon","display_name":"Ceylon cinnamon / Cinnamomum verum bark preparations","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The trial found a modest fasting-glucose signal, even though its main cholesterol result was negative.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ceylon-p39854533] Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39854533/ DOI: 10.1371/journal.pone.0317904","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Adults with LDL-C 100–190 mg/dL","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c43a7dea-5a21-53dd-894f-3f75733a788f","evidence_kind":"source_excerpt","locator":"Lines 1156-1167","start_line":1156,"end_line":1167,"excerpt":"### ceylon-trial-glucose\nFasting glucose reduction favored extract by an adjusted 8.59 mg/dL, 95% CI 0.59–16.59, p=0.036, on the secondary endpoint.\nCondition category: normal\nnutrient_topic: Ceylon cinnamon research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The trial found a modest fasting-glucose signal, even though its main cholesterol result was negative.\norganism: Human\ntissue_or_cell_type: Adults with LDL-C 100–190 mg/dL\nexperimental_model: Double-blind placebo-controlled randomized trial, complete-case analysis\nlimitations: LDL was primary and nonsignificant; fasting glucose was secondary. Missing follow-up, baseline metabolic status and preparation constrain generalization.\nexposure: 150 randomized, 127 assessed at 12 weeks; standardized extract 1000 mg/day\nevidence_span: {\"source_cache\": \"artifacts/ceylon-research/39854533.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5a891f5ed9907674aa119b8c697d009c06017b11d7e21e7959013853e3fd3443\", \"start_char\": 0, \"end_char\": 2414, \"text_sha256\": \"5a891f5ed9907674aa119b8c697d009c06017b11d7e21e7959013853e3fd3443\"}\n[ceylon-p39854533] Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39854533/ DOI: 10.1371/journal.pone.0317904","model_system":"Double-blind placebo-controlled randomized trial, complete-case analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ceylon-p39854533] Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial. 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