{"id":"877403c6-0f0c-5292-bdae-b9e0c8125459","stable_key":"availability:semet-mixed-metabolic-pools:2","predicate":"can_supply","statement":"SeMet can also be metabolized into the functional selenium pool.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"source_reported: Biochemical metabolism and source synthesis; not a claim of superiority in intervention trials.","direction":"positive","is_public":true,"mechanism_event_id":"72f5456e-26c1-51ed-8c97-5abae2708746","mechanism_event_label":"SeMet can also be metabolized into the functional selenium pool.","subject":{"id":"9ae8a163-7137-5610-800b-82ef311e28b9","slug":"selenomethionine","display_name":"Selenomethionine (SeMet)","entity_type_key":"small_molecule"},"object":{"id":"5bc4ebf6-26cd-5e8d-b496-54465bb696bb","slug":"functional-selenium-pool","display_name":"Functional selenium precursor pool","entity_type_key":"chemical_species"},"evidence_count":2,"mechanism_event":{"id":"72f5456e-26c1-51ed-8c97-5abae2708746","stable_key":"availability:semet-mixed-metabolic-pools:2","event_type":"availability_dependent_change","label":"SeMet can also be metabolized into the functional selenium pool.","description":"Selenomethionine contributes to measured selenium during exposure or repletion. Selenium-form pharmacokinetics and interpretation of status markers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9ae8a163-7137-5610-800b-82ef311e28b9","slug":"selenomethionine","display_name":"Selenomethionine (SeMet)","entity_type_key":"small_molecule"},"role":"condition_input","stoichiometry":null,"state_label":"Selenomethionine contributes to measured selenium during exposure or repletion.","sequence_order":0,"notes":""},{"entity":{"id":"5bc4ebf6-26cd-5e8d-b496-54465bb696bb","slug":"functional-selenium-pool","display_name":"Functional selenium precursor pool","entity_type_key":"chemical_species"},"role":"affected_component","stoichiometry":null,"state_label":"Selenomethionine contributes to measured selenium during exposure or repletion.","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"Selenomethionine contributes to measured selenium during exposure or repletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_scope","value_text":"Selenium-form pharmacokinetics and interpretation of status markers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Form alone does not determine clinical outcomes; baseline status, dose, duration, population, and endpoint matter. This comparison provides no product or dosing recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4cd15d62-8ee1-5195-8621-0661f18f5063","evidence_kind":"source_passage","locator":"lines 661-663","start_line":661,"end_line":663,"excerpt":"Selenomethionine (SeMet)\n\nWell absorbed; can enter the methionine pool and be nonspecifically incorporated into proteins, and can also be metabolized into the functional selenium pool","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}},{"id":"962b206a-dd32-53f5-8a59-152cb38add2d","evidence_kind":"source_passage","locator":"lines 681-681","start_line":681,"end_line":681,"excerpt":"Calling SeMet only “storage” and selenite only “functional” is too simple. Form changes pharmacokinetics and metabolism, but baseline status, dose, population, duration, endpoint, and study design also determine outcomes.","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}}],"relations":[],"conflicts":[],"corrections":[{"id":"cd342eaa-b8d6-5b3e-bdf1-abcd2346cef6","title":"SeMet can supply functional selenium as well as protein storage","kind":"contradiction","status":"corrected","why":"The earlier draft labels SeMet an inactive storage form. The new reference includes conversion into the functional selenium pool and explicitly rejects the storage-only description.","resolution":"Model both metabolic destinations. Trial results cannot be attributed conclusively to formulation alone.","created_at":"2026-09-17 05:59:32","record_type":"correction","display_label":"Correction history","record_url":"/corrections/cd342eaa-b8d6-5b3e-bdf1-abcd2346cef6","literature_review":{"revision_id":"80984e03-5f0f-5877-8094-afef7637444e","start_line":1704,"end_line":1709,"papers":[{"paper_key":"xia-2010","title":"Optimization of selenoprotein P and other plasma selenium biomarkers for the assessment of the selenium nutritional requirement: a placebo-controlled, double-blind study of selenomethionine supplementation in selenium-deficient Chinese subjects","url":"https://pubmed.ncbi.nlm.nih.gov/20573787/","doi":null,"year":2010,"model":"Randomized SeMet supplementation in selenium-deficient people","summary":"SeMet raises functional SELENOP and plasma GPX biomarkers."}]},"sides":[{"conflict_id":"cd342eaa-b8d6-5b3e-bdf1-abcd2346cef6","ordinal":0,"label":"Earlier statement","revision_id":"4cec6304-35d7-5560-9133-e6ea689db838","start_line":300,"end_line":302,"quote":"**SeMet is a storage form, not an active one.** It has no selenium-specific recognition — methionyl-tRNA synthetase can't tell Se from S, so SeMet gets **incorporated nonspecifically into albumin, hemoglobin, every protein in the body** at the Met positions. It raises plasma selenium beautifully and delivers almost no methylselenol.\n\nSELECT gave a selenium-replete population a storage compound. It was a null result waiting to happen.","claim_id":null,"source_key":"corrections","source_title":"Selenium corrections and deep dive","claim_ids":[]},{"conflict_id":"cd342eaa-b8d6-5b3e-bdf1-abcd2346cef6","ordinal":1,"label":"New reference qualification","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","start_line":661,"end_line":681,"quote":"Selenomethionine (SeMet)\n\nWell absorbed; can enter the methionine pool and be nonspecifically incorporated into proteins, and can also be metabolized into the functional selenium pool\n\nSelenium-enriched yeast\n\nMixture of selenium compounds, usually dominated by SeMet; composition varies by product\n\nSodium selenite\n\nInorganic selenium; metabolized toward reduced selenium intermediates; thiol-reactive and kinetically distinct from SeMet\n\nSodium selenate\n\nInorganic selenium that requires reduction before entering central selenium metabolism\n\nSe-methylselenocysteine\n\nDistinct metabolism and substantial experimental pharmacology; not interchangeable with ordinary nutritional dosing\n\nCalling SeMet only “storage” and selenite only “functional” is too simple. Form changes pharmacokinetics and metabolism, but baseline status, dose, population, duration, endpoint, and study design also determine outcomes.","claim_id":null,"source_key":"deficiency","source_title":"Selenium deficiency: a mechanism-first reference","claim_ids":[]}]}],"research":null}