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Proposed consequences for bone differentiation or cancer risk were not tested clinical outcomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Boron research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"boron","display_name":"Boron","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human DU-145 cells","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"These cells reorganized parts of their protein-making machinery as a mild stress response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[boron-p25425213] Boric acid induces cytoplasmic stress granule formation, eIF2α phosphorylation, and ATF4 in prostate DU-145 cells. (2015). https://pubmed.ncbi.nlm.nih.gov/25425213/ DOI: 10.1007/s10534-014-9809-5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Prostate cancer cell culture","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8683caec-96c8-59e7-afa3-da379dc41506","evidence_kind":"source_excerpt","locator":"Lines 365-376","start_line":365,"end_line":376,"excerpt":"### boron-stress-granules\nBoric-acid treatment induced stress granules and mild activation of the eIF2α/ATF4 response in DU-145 cells.\nCondition category: normal\nnutrient_topic: Boron research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: These cells reorganized parts of their protein-making machinery as a mild stress response.\norganism: Human DU-145 cells\ntissue_or_cell_type: Prostate cancer cell culture\nexperimental_model: Human prostate cancer cell stress-response assays\nlimitations: This study measured stress responses in a tumor cell line. Proposed consequences for bone differentiation or cancer risk were not tested clinical outcomes.\nexposure: Boric-acid exposure in the physiological-range conditions reported by the study\nevidence_span: {\"source_cache\": \"artifacts/boron-research/25425213.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5bd1560c24d673e3b1d1fc3d44f0c910ac981ffd2f53a3b90c6259f136c69fca\", \"start_char\": 0, \"end_char\": 1068, \"text_sha256\": \"5bd1560c24d673e3b1d1fc3d44f0c910ac981ffd2f53a3b90c6259f136c69fca\"}\n[boron-p25425213] Boric acid induces cytoplasmic stress granule formation, eIF2α phosphorylation, and ATF4 in prostate DU-145 cells. 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