{"id":"87489751-8de7-532c-8c7e-f9127adbea2c","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-mouse-stat5","predicate":"reduces_active_form","statement":"FGF21 reduced active hepatic STAT5 and expression of its target Igf1.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d0474444-648d-5387-a2e8-8b249ef7c8ef","mechanism_event_label":"A starvation signal weakened growth-hormone action.","subject":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"object":{"id":"3c7e188a-ee8d-566b-beb5-93d26e6a541f","slug":"mouse-stat5","display_name":"Mouse STAT5 transcription factors","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"d0474444-648d-5387-a2e8-8b249ef7c8ef","stable_key":"c9aa15a1-8ba2-5913-b2dd-372af304bf87:fast-mouse-stat5-event","event_type":"observed_relationship","label":"A starvation signal weakened growth-hormone action.","description":"FGF21 reduced active hepatic STAT5 and expression of its target Igf1.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8b01fe3c-a32b-5076-9c61-34d4d35e8b89","slug":"mouse-fgf21","display_name":"Mouse fibroblast growth factor 21 / Fgf21","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3c7e188a-ee8d-566b-beb5-93d26e6a541f","slug":"mouse-stat5","display_name":"Mouse STAT5 transcription factors","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a0ae437b-9274-567e-a489-6229fdd77559","slug":"mouse-igf1","display_name":"Mouse insulin-like growth factor 1 / Igf1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse FGF21 exposure experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Chronic experimental exposure is not an ordinary human overnight fast.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fasting","display_name":"Fasting / abstention from energy intake","entity_type_key":"cellular_process"}},{"dimension":"plain_language","value_text":"A starvation signal weakened growth-hormone action.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18585098/ · DOI 10.1016/j.cmet.2008.05.006","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"33d8eae6-e97b-5c35-b099-6c5ea81b9795","evidence_kind":"source_excerpt","locator":"Lines 264-270","start_line":264,"end_line":270,"excerpt":"## fast-mouse-stat5\nA starvation signal weakened growth-hormone action.\nFGF21 reduced active hepatic STAT5 and expression of its target Igf1.\nModel: Mouse FGF21 exposure experiments.\nLimitations: Chronic experimental exposure is not an ordinary human overnight fast.\nEvidence access: Primary abstract\nInhibition of growth hormone signaling by the fasting-induced hormone FGF21. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18585098/ · DOI 10.1016/j.cmet.2008.05.006","model_system":"Mouse FGF21 exposure experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"921d1eb5-2c88-52b9-9898-60b2b5bf6029","stable_key":"import-c9aa15a1-8ba2-5913-b2dd-372af304bf87","title":"Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"991b7fd94be84c0f1e622e0672eda03d600b388dfd7825e219aa1678d1c7983a","revision_id":"ce85d3f4-4eaf-5aee-bddb-0f0ce7fe2211","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}