{"id":"873e9af4-b568-5b3a-a2d8-573de1166ac9","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-human-atp-defect","predicate":"is_associated_with_reduction","statement":"The patient with SLC34A3-associated chronic hypophosphatemia had approximately 50% lower serum phosphate and muscle ATP synthetic flux.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7ca62c05-d230-5d63-aa88-72c0fd65263f","mechanism_event_label":"The study found a similar pattern in one person with inherited renal phosphate wasting.","subject":{"id":"ae914796-923f-5bd1-9b6b-3050fb9e5775","slug":"human-slc34a3-atp-study-genotype","display_name":"SLC34A3-associated phosphate wasting in the 2016 ATP-flux patient","entity_type_key":"protein_state"},"object":{"id":"31cb5a3d-e5e6-528f-bfc5-8395c826f0db","slug":"human-muscle-atp-synthetic-flux","display_name":"Human skeletal-muscle ATP synthetic flux by 31P-MRS","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7ca62c05-d230-5d63-aa88-72c0fd65263f","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-human-atp-defect-event","event_type":"observed_intervention","label":"The study found a similar pattern in one person with inherited renal phosphate wasting.","description":"The patient with SLC34A3-associated chronic hypophosphatemia had approximately 50% lower serum phosphate and muscle ATP synthetic flux.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fbd55ffd-f06d-59c2-b149-652d6250e673","slug":"slc34a3","display_name":"Sodium-phosphate cotransporter NaPi-IIc / SLC34A3","entity_type_key":"protein"},"role":"affected_transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ae914796-923f-5bd1-9b6b-3050fb9e5775","slug":"human-slc34a3-atp-study-genotype","display_name":"SLC34A3-associated phosphate wasting in the 2016 ATP-flux patient","entity_type_key":"protein_state"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"31cb5a3d-e5e6-528f-bfc5-8395c826f0db","slug":"human-muscle-atp-synthetic-flux","display_name":"Human skeletal-muscle ATP synthetic flux by 31P-MRS","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/27338702.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"634bc9a26ebb8d6a911692bcb98a05432db2bc08455c0a02f1ef5e4b953150fe\", \"start_char\": 0, \"end_char\": 1786, \"text_sha256\": \"634bc9a26ebb8d6a911692bcb98a05432db2bc08455c0a02f1ef5e4b953150fe\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"31P-MRS ATP-flux measurements, repletion and cellular/mitochondrial experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Diet-induced low phosphate, NaPi-IIa knockout, phosphate repletion; one SLC34A3-associated human case","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"ATP synthetic flux is not ATP pool size or direct proof that all measured flux is mitochondrial oxidative phosphorylation. One human case cannot define a population threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The study found a similar pattern in one person with inherited renal phosphate wasting.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p27338702] Hypophosphatemia promotes lower rates of muscle ATP synthesis. 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One human case cannot define a population threshold.\nexposure: Diet-induced low phosphate, NaPi-IIa knockout, phosphate repletion; one SLC34A3-associated human case\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/27338702.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"634bc9a26ebb8d6a911692bcb98a05432db2bc08455c0a02f1ef5e4b953150fe\", \"start_char\": 0, \"end_char\": 1786, \"text_sha256\": \"634bc9a26ebb8d6a911692bcb98a05432db2bc08455c0a02f1ef5e4b953150fe\"}\n[phosphorus-p27338702] Hypophosphatemia promotes lower rates of muscle ATP synthesis. (2016). https://pubmed.ncbi.nlm.nih.gov/27338702/ DOI: 10.1096/fj.201600473r","model_system":"31P-MRS ATP-flux measurements, repletion and cellular/mitochondrial experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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