{"id":"871b6bf7-c923-567f-b5de-53a4b743c79d","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-intestinal-ctr1-systemic","predicate":"deletion_impairs","statement":"Intestinal Ctr1 deletion reduced peripheral copper availability and caused neonatal growth failure and cardiac hypertrophy in mice.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"96fc56bb-f160-5379-a9d3-f878c926067a","mechanism_event_label":"Copper in food is not enough if the intestine cannot deliver it to the body.","subject":{"id":"9b443d47-b3cc-538d-ad34-e93b5c7880c8","slug":"mouse-slc31a1","display_name":"Mouse copper transporter Ctr1 / Slc31a1","entity_type_key":"protein"},"object":{"id":"979842b5-a055-50fa-806d-c8254b050470","slug":"systemic-copper-delivery","display_name":"Delivery of intestinal copper to peripheral tissues","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"96fc56bb-f160-5379-a9d3-f878c926067a","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-intestinal-ctr1-systemic-event","event_type":"biochemical_relationship","label":"Copper in food is not enough if the intestine cannot deliver it to the body.","description":"Intestinal Ctr1 deletion reduced peripheral copper availability and caused neonatal growth failure and cardiac hypertrophy in mice.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9b443d47-b3cc-538d-ad34-e93b5c7880c8","slug":"mouse-slc31a1","display_name":"Mouse copper transporter Ctr1 / Slc31a1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"979842b5-a055-50fa-806d-c8254b050470","slug":"systemic-copper-delivery","display_name":"Delivery of intestinal copper to peripheral tissues","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/16950140.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"08532f69fd9530033f8d9afcece9249fc50dd425f57313e120f55ea81cee8f98\", \"start_char\": 0, \"end_char\": 1026, \"text_sha256\": \"08532f69fd9530033f8d9afcece9249fc50dd425f57313e120f55ea81cee8f98\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Intestinal epithelial Ctr1 knockout mice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Intestinal Ctr1 deletion; postnatal copper rescue","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Genetic intestinal transport failure differs from low dietary intake. The indexed abstract does not establish the administration route of the rescue dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Copper in food is not enough if the intestine cannot deliver it to the body.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p16950140] Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. (2006). https://pubmed.ncbi.nlm.nih.gov/16950140/ DOI: 10.1016/j.cmet.2006.08.009","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine and peripheral organs","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"dd392350-8d04-5d95-ab12-79d60b8826e6","evidence_kind":"source_excerpt","locator":"Lines 312-323","start_line":312,"end_line":323,"excerpt":"### copper-intestinal-ctr1-systemic\nIntestinal Ctr1 deletion reduced peripheral copper availability and caused neonatal growth failure and cardiac hypertrophy in mice.\nCondition category: machinery_impairment\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Copper in food is not enough if the intestine cannot deliver it to the body.\norganism: Mouse\ntissue_or_cell_type: Intestine and peripheral organs\nexperimental_model: Intestinal epithelial Ctr1 knockout mice\nlimitations: Genetic intestinal transport failure differs from low dietary intake. The indexed abstract does not establish the administration route of the rescue dose.\nexposure: Intestinal Ctr1 deletion; postnatal copper rescue\nevidence_span: {\"source_cache\": \"artifacts/copper-research/16950140.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"08532f69fd9530033f8d9afcece9249fc50dd425f57313e120f55ea81cee8f98\", \"start_char\": 0, \"end_char\": 1026, \"text_sha256\": \"08532f69fd9530033f8d9afcece9249fc50dd425f57313e120f55ea81cee8f98\"}\n[copper-p16950140] Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. (2006). https://pubmed.ncbi.nlm.nih.gov/16950140/ DOI: 10.1016/j.cmet.2006.08.009","model_system":"Intestinal epithelial Ctr1 knockout mice","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p16950140] Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. (2006). https://pubmed.ncbi.nlm.nih.gov/16950140/ DOI: 10.1016/j.cmet.2006.08.009","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"84b0f62b2dae6835fa26902be87625c003c6c707492d3007e8f9d15420669008","revision_id":"d7e35b8b-3f77-56d9-90b5-5f542c63f321","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}