{"id":"871b15a4-2313-510c-aba2-e170537fc674","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-taurine-negative","predicate":"did_not_change","statement":"Ten weeks of beta-alanine supplementation did not change muscle taurine in this study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ce8f98d1-63dc-56cf-8229-afc0f7f60ad7","mechanism_event_label":"A proposed precursor interaction did not cause measurable depletion here.","subject":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"object":{"id":"393b7724-c6d3-5ff1-9760-f3226a425911","slug":"human-muscle-taurine-content","display_name":"Human skeletal-muscle taurine content","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ce8f98d1-63dc-56cf-8229-afc0f7f60ad7","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-taurine-negative-event","event_type":"observed_relationship","label":"A proposed precursor interaction did not cause measurable depletion here.","description":"Ten weeks of beta-alanine supplementation did not change muscle taurine in this study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"288f19a6-62f0-51fe-8e6d-366388b6b16d","slug":"beta-alanine","display_name":"Beta-alanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"393b7724-c6d3-5ff1-9760-f3226a425911","slug":"human-muscle-taurine-content","display_name":"Human skeletal-muscle taurine content","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human muscle-biopsy study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not exclude effects under other exposures or in other species.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A proposed precursor interaction did not cause measurable depletion here.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16868650/ · DOI 10.1007/s00726-006-0364-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a72ae2aa-225e-5f83-8e23-bd8d9ab87194","evidence_kind":"source_excerpt","locator":"Lines 220-226","start_line":220,"end_line":226,"excerpt":"## carnosine-taurine-negative\nA proposed precursor interaction did not cause measurable depletion here.\nTen weeks of beta-alanine supplementation did not change muscle taurine in this study.\nModel: Human muscle-biopsy study.\nLimitations: Does not exclude effects under other exposures or in other species.\nEvidence access: Primary abstract\nInfluence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. · 2007 · https://pubmed.ncbi.nlm.nih.gov/16868650/ · DOI 10.1007/s00726-006-0364-4","model_system":"Human muscle-biopsy study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"469cbc38203db56bd031f9d8a2dd2bfa387713950ca30199511cd137e927aa7a","revision_id":"cc409a15-8b04-50ee-a7ff-d1bf32f686bb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}