{"id":"87035b9c-a03d-562b-999a-85451a5750a6","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-exercise-utilization","predicate":"increases_relative_to_glucose","statement":"Whole-body carbohydrate utilization during cycling was greater with sucrose than glucose, 2.03 versus 1.66 g/min.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"1fac68b0-8586-531b-bef9-f1ee5f22cd6c","mechanism_event_label":"Whole-body carbohydrate utilization during cycling was greater with sucrose than glucose, 2.03 versus 1.66 g/min.","subject":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"object":{"id":"741c8e31-d6a2-5df2-a160-9c74b324feae","slug":"human-exercise-carbohydrate-oxidation","display_name":"Human whole-body carbohydrate utilization during exercise","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1fac68b0-8586-531b-bef9-f1ee5f22cd6c","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-exercise-utilization-event","event_type":"observed_relationship","label":"Whole-body carbohydrate utilization during cycling was greater with sucrose than glucose, 2.03 versus 1.66 g/min.","description":"Whole-body carbohydrate utilization during cycling was greater with sucrose than glucose, 2.03 versus 1.66 g/min.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"741c8e31-d6a2-5df2-a160-9c74b324feae","slug":"human-exercise-carbohydrate-oxidation","display_name":"Human whole-body carbohydrate utilization during exercise","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Sucrose or glucose 1.7 g/min, 102 g/hour, during cycling at 50% peak power","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"3 hours","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract/metadata; unrecovered methods explicitly retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"14 trained cyclists in crossover; four completed additional water reference trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Exercise fuel, not sedentary beverage exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Water reference had four participants, not all 14. Whole-body utilization is not isolated exogenous sucrose oxidation. No demonstrated sucrose advantage for liver glycogen preservation. NCT02110836; Sugar Nutrition UK sponsor listed in trial record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"14 trained cyclists in crossover; four completed additional water reference trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Whole-body carbohydrate utilization during cycling was greater with sucrose than glucose, 2.03 versus 1.66 g/min.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists. (2015). https://pubmed.ncbi.nlm.nih.gov/26487008/ DOI: 10.1152/ajpendo.00376.2015","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral carbohydrate during exercise","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Liver and muscle glycogen by carbon-13 MRS; expired-gas substrate use","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e1aac80b-0ed3-5b2e-b454-3f23702adeed","evidence_kind":"source_excerpt","locator":"Lines 319-329","start_line":319,"end_line":329,"excerpt":"## sucrose-exercise-utilization\nWhole-body carbohydrate utilization during cycling was greater with sucrose than glucose, 2.03 versus 1.66 g/min.\nModel/species: 14 trained cyclists in crossover; four completed additional water reference trial\nTissue: Liver and muscle glycogen by carbon-13 MRS; expired-gas substrate use\nExposure: Sucrose or glucose 1.7 g/min, 102 g/hour, during cycling at 50% peak power\nRoute: Oral carbohydrate during exercise\nDuration: 3 hours\nExposure scope: Exercise fuel, not sedentary beverage exposure\nLimits: Water reference had four participants, not all 14. Whole-body utilization is not isolated exogenous sucrose oxidation. No demonstrated sucrose advantage for liver glycogen preservation. NCT02110836; Sugar Nutrition UK sponsor listed in trial record.\nReference: Ingestion of glucose or sucrose prevents liver but not muscle glycogen depletion during prolonged endurance-type exercise in trained cyclists. (2015). https://pubmed.ncbi.nlm.nih.gov/26487008/ DOI: 10.1152/ajpendo.00376.2015\nAccess: Primary abstract/metadata; unrecovered methods explicitly retained.","model_system":"14 trained cyclists in crossover; four completed additional water reference trial","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text.","file_path":"","sha256":"5e68ccbade7a80fc03778495756f0eeeeba5038cd10d5bef8e33cb1e93e4b044","revision_id":"6edb8ffc-11c5-5cd9-852c-85adb71165a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}