{"id":"86fadc82-5ac2-5630-b32b-83f199658247","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-resveratrol-addition","predicate":"additive_with","statement":"Myricetin plus resveratrol inhibited TPA/EGF-induced mouse JB6 transformation additively, not synergistically.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"82301caa-cfd5-586b-90c7-d1186774477e","mechanism_event_label":"Two active compounds did not demonstrate synergy in this test.","subject":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"object":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"82301caa-cfd5-586b-90c7-d1186774477e","stable_key":"8182578e-8d21-598e-a3cb-e62d480d2251:myricetin-resveratrol-addition-event","event_type":"observed_relationship","label":"Two active compounds did not demonstrate synergy in this test.","description":"Myricetin plus resveratrol inhibited TPA/EGF-induced mouse JB6 transformation additively, not synergistically.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"fafe05e7-4874-56e6-a42a-2ebf1ab2dd57","slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse epidermal cells; study compared 10 micromolar myricetin and 20 micromolar resveratrol.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay-specific interaction, not a universal combination verdict.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Myricetin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"myricetin","display_name":"Myricetin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Two active compounds did not demonstrate synergy in this test.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17693661/ · DOI 10.1093/carcin/bgm110","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8deee2af-55d1-5bc7-ada2-d6a323474c7d","evidence_kind":"source_excerpt","locator":"Lines 460-466","start_line":460,"end_line":466,"excerpt":"## myricetin-resveratrol-addition\nTwo active compounds did not demonstrate synergy in this test.\nMyricetin plus resveratrol inhibited TPA/EGF-induced mouse JB6 transformation additively, not synergistically.\nModel: Mouse epidermal cells; study compared 10 micromolar myricetin and 20 micromolar resveratrol.\nLimitations: Assay-specific interaction, not a universal combination verdict.\nEvidence access: Primary abstract\nMyricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17693661/ · DOI 10.1093/carcin/bgm110","model_system":"Mouse epidermal cells; study compared 10 micromolar myricetin and 20 micromolar resveratrol.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"58045cd9-3b27-5469-bb4b-e1c6a9bdca34","stable_key":"import-8182578e-8d21-598e-a3cb-e62d480d2251","title":"Myricetin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"0abf512275cf3aae9e4ec8544f1cde97e0155d0cfb5be12a193cdd5a898386a7","revision_id":"422e342f-a55c-5e73-ba98-43df560f49b9","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}