{"id":"86d3aa2e-cac2-54ee-9dd8-72ebd859f847","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-marathon-weight","predicate":"associated_with_low","statement":"Weight gain during the marathon was independently associated with hyponatremia, odds ratio 4.2 (95% CI 2.2–8.2).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"662bc2bd-b7fb-5866-a0f8-5b0ebc4c29db","mechanism_event_label":"A low sodium concentration can accompany gaining water rather than simply losing salt.","subject":{"id":"976cacfb-7e81-5e78-8a75-a921cea8ada7","slug":"exercise-associated-weight-gain","display_name":"Weight gain during endurance exercise","entity_type_key":"cellular_process"},"object":{"id":"da7ca55c-2632-5eb7-b91c-94885c90d27e","slug":"plasma-sodium-concentration","display_name":"Plasma or serum sodium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"662bc2bd-b7fb-5866-a0f8-5b0ebc4c29db","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-marathon-weight-event","event_type":"observed_intervention","label":"A low sodium concentration can accompany gaining water rather than simply losing salt.","description":"Weight gain during the marathon was independently associated with hyponatremia, odds ratio 4.2 (95% CI 2.2–8.2).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d31225b7-8e94-5857-9ea1-67ac794b1f15","slug":"water","display_name":"H2O","entity_type_key":"small_molecule"},"role":"balance_context","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"976cacfb-7e81-5e78-8a75-a921cea8ada7","slug":"exercise-associated-weight-gain","display_name":"Weight gain during endurance exercise","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"da7ca55c-2632-5eb7-b91c-94885c90d27e","slug":"plasma-sodium-concentration","display_name":"Plasma or serum sodium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/15829535.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9bf7f638ff3cfcad3d43536a75ffedf40a2ef726f783922f3169c9252c12a8e5\", \"start_char\": 0, \"end_char\": 1893, \"text_sha256\": \"9bf7f638ff3cfcad3d43536a75ffedf40a2ef726f783922f3169c9252c12a8e5\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective marathon cohort with prerace/postrace weights and blood sampling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2002 Boston Marathon; 488 usable finish-line blood samples","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Observational associations and sampling limitations; fluid composition was not independently associated. Not a treatment protocol or pure dietary-depletion study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human runners","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A low sodium concentration can accompany gaining water rather than simply losing salt.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p15829535] Hyponatremia among runners in the Boston Marathon. (2005). https://pubmed.ncbi.nlm.nih.gov/15829535/ DOI: 10.1056/nejmoa043901","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic water/sodium balance","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"f9036d89-fae7-5e52-95a4-a312efd46e11","evidence_kind":"source_excerpt","locator":"Lines 1006-1017","start_line":1006,"end_line":1017,"excerpt":"### sodium-marathon-weight\nWeight gain during the marathon was independently associated with hyponatremia, odds ratio 4.2 (95% CI 2.2–8.2).\nCondition category: biomarker_context\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A low sodium concentration can accompany gaining water rather than simply losing salt.\norganism: Human runners\ntissue_or_cell_type: Systemic water/sodium balance\nexperimental_model: Prospective marathon cohort with prerace/postrace weights and blood sampling\nlimitations: Observational associations and sampling limitations; fluid composition was not independently associated. Not a treatment protocol or pure dietary-depletion study.\nexposure: 2002 Boston Marathon; 488 usable finish-line blood samples\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/15829535.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9bf7f638ff3cfcad3d43536a75ffedf40a2ef726f783922f3169c9252c12a8e5\", \"start_char\": 0, \"end_char\": 1893, \"text_sha256\": \"9bf7f638ff3cfcad3d43536a75ffedf40a2ef726f783922f3169c9252c12a8e5\"}\n[sodium-p15829535] Hyponatremia among runners in the Boston Marathon. (2005). https://pubmed.ncbi.nlm.nih.gov/15829535/ DOI: 10.1056/nejmoa043901","model_system":"Prospective marathon cohort with prerace/postrace weights and blood sampling","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p15829535] Hyponatremia among runners in the Boston Marathon. (2005). https://pubmed.ncbi.nlm.nih.gov/15829535/ DOI: 10.1056/nejmoa043901","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c260cd7b-beb0-5113-a198-69ec8fd4492c","stable_key":"import-195e8b84-ca5a-591a-a045-c55c53c8a01c","title":"Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"684f65cf0661c18395831ade4b02bb24d5e66c568f0d00a3471600eaf5d4d1c6","revision_id":"39866f04-3052-5f59-bd95-6806c5490875","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}