{"id":"861293d4-1b06-5c01-8485-47ce5232d307","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-fecal-bile-trend","predicate":"tended_to_increase","statement":"Fecal bile-acid excretion tended to increase; nasunin and delphinidin effects did not differ.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7191accf-f6da-5a0f-b036-ff5ad6596bc8","mechanism_event_label":"The comparison does not establish a unique nasunin advantage.","subject":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"object":{"id":"7fe3588e-3023-5e7b-8a36-8c4ca76d1f30","slug":"rat-fecal-bile-acids","display_name":"Rat fecal bile-acid excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7191accf-f6da-5a0f-b036-ff5ad6596bc8","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-fecal-bile-trend-event","event_type":"observed_intervention","label":"The comparison does not establish a unique nasunin advantage.","description":"Fecal bile-acid excretion tended to increase; nasunin and delphinidin effects did not differ.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"35f028a1-9a8b-5983-8d02-53c5fb091d38","slug":"delphinidin","display_name":"Delphinidin","entity_type_key":"small_molecule"},"role":"comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7fe3588e-3023-5e7b-8a36-8c4ca76d1f30","slug":"rat-fecal-bile-acids","display_name":"Rat fecal bile-acid excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/lipids1994.publisher-abstract.txt\", \"locator\": \"Primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5f7c22d653590116df8a923aba127ecd7c7baa3d0b2224df4e73b83d11361cc4\", \"start_char\": 0, \"end_char\": 980, \"text_sha256\": \"5f7c22d653590116df8a923aba127ecd7c7baa3d0b2224df4e73b83d11361cc4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cholesterol-enriched feeding comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nasunin versus delphinidin supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract reports trends, not established significant clinical effects. Proposed reduced absorption was an interpretation, not a demonstrated transporter mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The comparison does not establish a unique nasunin advantage.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-plipids1994] Effects of Dietary Nasunin on the Serum Cholesterol Level in Rats (1994). https://www.jstage.jst.go.jp/article/bbb1992/58/3/58_3_570/_article/-char/en DOI: 10.1271/bbb.58.570","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum lipids and fecal excretion","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4e61b6bb-65e6-5a89-8717-866b24727b1f","evidence_kind":"source_excerpt","locator":"Lines 978-989","start_line":978,"end_line":989,"excerpt":"### nasunin-fecal-bile-trend\nFecal bile-acid excretion tended to increase; nasunin and delphinidin effects did not differ.\nCondition category: normal\nnutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The comparison does not establish a unique nasunin advantage.\norganism: Rats\ntissue_or_cell_type: Serum lipids and fecal excretion\nexperimental_model: Cholesterol-enriched feeding comparison\nlimitations: The abstract reports trends, not established significant clinical effects. Proposed reduced absorption was an interpretation, not a demonstrated transporter mechanism.\nexposure: Nasunin versus delphinidin supplementation\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/lipids1994.publisher-abstract.txt\", \"locator\": \"Primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5f7c22d653590116df8a923aba127ecd7c7baa3d0b2224df4e73b83d11361cc4\", \"start_char\": 0, \"end_char\": 980, \"text_sha256\": \"5f7c22d653590116df8a923aba127ecd7c7baa3d0b2224df4e73b83d11361cc4\"}\n[nasunin-plipids1994] Effects of Dietary Nasunin on the Serum Cholesterol Level in Rats (1994). https://www.jstage.jst.go.jp/article/bbb1992/58/3/58_3_570/_article/-char/en DOI: 10.1271/bbb.58.570","model_system":"Cholesterol-enriched feeding comparison","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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